Analyses of spindle genes with missense changes in modern humans reveal evidence for positive selection since the split with archaic humans and show that modern humans interacted with Neandertals more than once in the past 200,000 years.

Key functional variants, discovered using Massively Parallel Reporter Assay (MPRA) and reporter assays in the context of SARS-CoV-2 infection, support the importance of two critical chemokine receptor genes CCR1 and CCR5 in severe Covid-19 illness.

Genetic variants introgressed into modern humans from Neanderthals tend to be depleted in their contribution to heritable trait variation relative to modern human variants consistent with the action of purifying selection.

Genomic polymorphism across centromeric regions of humans is organized into large-scale haplotypes with great diversity, including entire Neanderthal centromeres.

Graph genotyping of structural variation in diverse human populations reveals functional associations and signatures of local adaptation within poorly resolved regions of the genome.

Purine biosynthesis is reduced in humans due to a single amino acid substitution in adenylosuccinate lyase that occurred subsequent to the divergence of modern humans from Neandertals.

The effect of balancing selection on the human genome is greater than previously appreciated, especially affecting large deletion variations.

Convolutional neural networks are an effective tool for detecting archaic adaptive introgression from genomic data.

Newly recovered lumbar vertebrae belonging to Malapa Hominin 2, an adult female of the fossil hominin species Australopithecus sediba, demonstrate that this individual was adapted to upright posture and bipedal locomotion but also had adaptations for climbing in trees.