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    1. Neuroscience

    Eco-HAB as a fully automated and ecologically relevant assessment of social impairments in mouse models of autism

    Alicja Puścian, Szymon Łęski ... Ewelina Knapska
    An innovative, fully computerized approach for measuring spontaneous social behavior in mice closely follows murine ethology, eliminates crucial sources of data irreproducibility and enables fast, inexpensive assessment of sociability in group-housed subjects.
    1. Cell Biology

    Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly

    Sari Tojkander, Gergana Gateva ... Pekka Lappalainen
    Mechanosensitive inhibition of actin polymerization through VASP phosphorylation is required for stress fiber maturation and alignment.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation

    Victoria Hung, Stephanie S Lam ... Alice Y Ting
    One minute biotinylation with APEX2 peroxidase in living cells identifies established and new components of mitochondrial and ER membranes; dataset intersection and overexpression screen identifies SYNJ2BP overexpression as inducing mitochondria-rough ER contacts.
    1. Neuroscience

    Conserved visual capacity of rats under red light

    Nader Nikbakht, Mathew E Diamond
    Psychometric measures reveal that, contrary to common assumption, rats have good visual form discrimination capacity under red and even far-red illumination.
    1. Structural Biology and Molecular Biophysics

    RNA tertiary structure and conformational dynamics revealed by BASH MaP

    Maxim Oleynikov, Samie R Jaffrey
    BASH MaP quantitatively reveals alternative RNA tertiary structures by enabling dimethyl sulfate to probe the presence of nucleobase interactions on the Watson-Crick and Hoogsteen faces of single RNA molecules.
    1. Developmental Biology

    Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway

    Hyae Yon Kweon, Mi-Ni Lee ... Gholson J Lyon
    Mice doubly deficient for Naa10 and Naa12 display embryonic lethality, with both enzymes compensating for each other with amino-terminal acetylation of proteins in mouse development.
    1. Cell Biology
    2. Neuroscience

    Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans

    Jamie L Courtland, Tyler WA Bradshaw ... Scott H Soderling
    Cellular etiology of a human WASH complex mutation in mice reveals its specific roles in neuronal organelle trafficking and a surprising role in motor impairments.
    1. Neuroscience

    Effects of noise and metabolic cost on cortical task representations

    Jake Patrick Stroud, Michal Wojcik ... Mate Lengyel
    The dynamical solutions exhibited by task-optimized recurrent neural networks, and their similarity to prefrontal cortex dynamics, depends strongly on the strength of neural noise and metabolic cost imposed during training.
    1. Neuroscience

    A hierarchical, retinotopic proto-organization of the primate visual system at birth

    Michael J Arcaro, Margaret S Livingstone
    A retinotopic proto-organization present at birth provides the infrastructure for the subsequent development of visual cortex that commences at the onset of visual experience.
    1. Cell Biology
    2. Computational and Systems Biology

    Self-establishing communities enable cooperative metabolite exchange in a eukaryote

    Kate Campbell, Jakob Vowinckel ... Markus Ralser
    A eukaryotic cell model overcomes metabolic deficiencies within a complex, self-establishing community that enables the growth-relevant exchange of metabolic intermediates.