16 results found
    1. Microbiology and Infectious Disease

    RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates

    Samantha G Palace et al.
    Ceftriaxone resistance has arisen multiple times in clinical gonococcal populations via previously undescribed RNA polymerase mutations, underscoring the importance of continued surveillance for novel resistance determinants.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Antibiotic Resistance: Genomics against gonorrhoea

    Nicholas Medland
    Surveillance strategies based on whole genome sequencing could help with the early identification and detection of new forms of drug-resistant gonorrhoea.
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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Targeted surveillance strategies for efficient detection of novel antibiotic resistance variants

    Allison L Hicks et al.
    Sampling informed by pathogen genomic data may facilitate more efficient detection of novel antibiotic resistance than random sampling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Insights into the key determinants of membrane protein topology enable the identification of new monotopic folds

    Sonya Entova et al.
    Key sequence motifs, defined using the first reported structure of a monotopic membrane protein with a reentrant helix, enable identification of new monotopic membrane protein families previously predicted as membrane spanning.
    1. Structural Biology and Molecular Biophysics

    Structure of a type IV pilus machinery in the open and closed state

    Vicki AM Gold et al.
    Electron cryo-tomography reveals a huge conformational change in the secretin domain of the type IV pilus machinery that occurs when the channel opens for pilus extrusion.
    1. Microbiology and Infectious Disease

    The Mla pathway in Acinetobacter baumannii has no demonstrable role in anterograde lipid transport

    Matthew J Powers et al.
    An outer membrane vesicle pulse-chase assay demonstrates that the Acinetobacter baumannii Mla system is a retrograde lipid transporter.
    1. Microbiology and Infectious Disease

    Bacterial symbiont subpopulations have different roles in a deep-sea symbiosis

    Tjorven Hinzke et al.
    Physiological differentiation during symbiosis leads to division of labor between smaller and larger cells in an uncultured bacterial tubeworm symbiont population and results in remarkable metabolic diversity and complexity.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evolutionary pathways to antibiotic resistance are dependent upon environmental structure and bacterial lifestyle

    Alfonso Santos-Lopez et al.
    Bacteria growing in biofilms evolve antimicrobial resistance via different pathways and generate greater genetic diversity than well-mixed populations, selecting fitter but less resistant genotypes.
    1. Microbiology and Infectious Disease

    Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis

    Allison Hillary Williams et al.
    Lytic transglycosylase enhances the activity of its protein partner, and its catalytic domain can be targeted to disrupt cell-wall integrity, protein partner function, and bacterial survival (Neisseria meningitidis) in hosts.
    1. Medicine
    2. Microbiology and Infectious Disease

    Mucosal effects of tenofovir 1% gel

    Florian Hladik et al.
    Mucosal application of the anti-retroviral drug tenofovir, which is intended to prevent HIV transmission, has many off-target effects on the mucosa itself.

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