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    1. Neuroscience

    CA1 pyramidal cell diversity is rooted in the time of neurogenesis

    Davide Cavalieri, Alexandra Angelova ... Rosa Cossart
    Embryonic birthdate is a crucial determinant of heterogeneity among CA1 principal neurons, which include a previously overlooked subpopulation of pioneer neurons.
    1. Evolutionary Biology
    2. Neuroscience

    A small, computationally flexible network produces the phenotypic diversity of song recognition in crickets

    Jan Clemens, Stefan Schöneich ... Berthold Hedwig
    A computational model of the neuronal network that recognizes mating signals reveals network properties that support and constrain behavioral diversity in a species group.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation

    Jelle van den Ameele, Andrea H Brand
    Mitochondrial dysfunction in neural stem cells and brain tumour cells decreases proliferation and affects the generation of neuronal diversity and tumour heterogeneity.
    1. Neuroscience

    Synaptic interactions between stellate cells and parvalbumin interneurons in layer 2 of the medial entorhinal cortex are organized at the scale of grid cell clusters

    Li-Wen Huang, Derek LF Garden ... Matthew F Nolan
    New methods for investigating connectivity between genetically defined neuronal populations are introduced and used to investigate the organisation of excitatory-inhibitory interactions in the superficial entorhinal cortex.
    1. Developmental Biology

    Mamo decodes hierarchical temporal gradients into terminal neuronal fate

    Ling-Yu Liu, Xi Long ... Tzumin Lee
    Neuronal diversity is expanded by a temporal fating paradigm utilizing hierarchical gene regulation.
    1. Neuroscience

    Cellular taxonomy and spatial organization of the murine ventral posterior hypothalamus

    Laura E Mickelsen, William F Flynn ... Alexander C Jackson
    Single cell RNA–sequencing and neuroanatomical methods reveal unexpected molecular diversity and highly segregated spatial organization of neuronal cell types within the mouse ventral posterior hypothalamus, including the mammillary nuclei.
    1. Neuroscience

    Lognormal firing rate distribution reveals prominent fluctuation–driven regime in spinal motor networks

    Peter C Petersen, Rune W Berg
    Neuronal participation in generation of motor patterns in the spinal circuits is lognormal, which is an indication of a rich diversity of activity within the mean-driven as well as the fluctuation-driven regimes.
    1. Genetics and Genomics
    2. Neuroscience

    Machine learning sequence prioritization for cell type-specific enhancer design

    Alyssa J Lawler, Easwaran Ramamurthy ... Andreas R Pfenning
    A new cross-species machine learning-based strategy is applied to find enhancers that specifically label parvalbumin neurons in the mouse and macaque.
    1. Genetics and Genomics
    2. Neuroscience

    Layer-specific chromatin accessibility landscapes reveal regulatory networks in adult mouse visual cortex

    Lucas T Gray, Zizhen Yao ... Bosiljka Tasic
    ATAC-seq, transcriptomics, and transcription factor motif searches collaborate to build a network that regulates gene expression in different cortical layers.
    1. Developmental Biology
    2. Neuroscience

    A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture

    Alfredo Llorca, Gabriele Ciceri ... Oscar Marin
    The specification of a very small number of progenitor cells with competence to adapt their neurogenic output to different probabilistic rules underlies the generation of distinct cortical cytoarchitectures.