347 results found
    1. Cell Biology
    2. Immunology and Inflammation

    Diverse stimuli engage different neutrophil extracellular trap pathways

    Elaine F Kenny et al.
    NETs induction, a central component of the innate immune response, utilises assorted signalling pathways as demonstrated through the analysis of healthy and patient neutrophils treated with five distinct stimuli.
    1. Immunology and Inflammation

    IL-21/type I interferon interplay regulates neutrophil-dependent innate immune responses to Staphylococcus aureus

    Rosanne Spolski et al.
    Neutrophil-dependent innate immune responses to the human pathogen, methicillin-resistant Staphylococcus aureus, are modulated by an interplay between interleukin-21 and type 1 interferons.
    1. Cell Biology

    Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets

    Pierre Cunin et al.
    In a novel cell-in-cell interaction termed emperipolesis, neutrophils routinely transit through the cytoplasm of bone marrow megakaryocytes to pass surface membrane to newly-generated hybrid platelets.
    1. Immunology and Inflammation

    Endothelial cell-derived CD95 ligand serves as a chemokine in induction of neutrophil slow rolling and adhesion

    Liang Gao et al.
    The cell surface protein CD95 mediates neutrophil slow rolling and adhesion during inflammation.
    1. Immunology and Inflammation

    Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-β1 and PILR-α

    Yu-Tung Li et al.
    Blood flow-driven shear forces guide the sequential signaling of two antagonistic paired receptors, a critical bi-facet step that first supports leukocyte docking, then initiates transmigration through endothelium.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Neutrophil-generated HOCl leads to non-specific thiol oxidation in phagocytized bacteria

    Adriana Degrossoli et al.
    The use of genetically encoded redox sensors in phagocytized bacteria reveals that, among the toxic cocktail of oxidants released into the neutrophil's phagolysosome, HOCl is the main component responsible for the oxidative modification of bacterial protein thiols.
    1. Cell Biology

    Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes

    Lillian K Fritz-Laylin et al.
    Neutrophil pseudopods are composed of multiple sheets that are inherently flat, protrude in three dimensions, and whose assembly correlates with cell turning.
    1. Structural Biology and Molecular Biophysics
    2. Human Biology and Medicine

    Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood

    Nicole Toepfner et al.
    The morphology and deformability of all blood cells can be measured continuously and with high throughput directly in whole blood without prior enrichment or separation.

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