179 results found
    1. Cell Biology
    2. Developmental Biology

    Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration

    Lu Wei et al.
    Notch signaling controls the collective migration of parapineal cells through its capacity to restrict FGF pathway activation to a few leading cells.
    1. Neuroscience

    Neuropeptide F regulates courtship in Drosophila through a male-specific neuronal circuit

    Weiwei Liu et al.
    Functional dissection of a cluster of male-specific neurons in Drosophila reveals a neuronal circuit regulating male courtship in accordance with the internal drive state.
    1. Neuroscience

    Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels

    Francesco Tomassoni-Ardori et al.
    RbFox1 upregulation modulates the expression of hundreds of genes but only dysregulation of the TrkB.T1 receptor isoform expression causes BDNF-dependent LTP impairments.
    1. Cell Biology
    2. Human Biology and Medicine

    Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness

    Arpit Sharma et al.
    Skeletal muscle mitochondrial pyruvate carrier disruption increases muscle fatty acid oxidation and systemic glucose turnover that drive whole-body leanness.
    1. Developmental Biology
    2. Neuroscience

    Sox1a mediates the ability of the parapineal to impart habenular left-right asymmetry

    Ingrid Lekk et al.
    The sox1a gene is required for a small group on neurons on the left side of the brain to influence the generation and left-sided character of their future synaptic partners.
    1. Immunology and Inflammation

    The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets

    Takuya Koike et al.
    Unveiling a mechanism for the fate decision of B-cell differentiation into two functionally distinct memory B cell subsets.
    1. Cell Biology
    2. Neuroscience

    Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons

    Andrea KH Stavoe et al.
    The dynamic phosphorylation of autophagy component WIPI2B is critical to maintain autophagosome biogenesis in neurons, and ectopic expression of WIPI2B can restore rates of autophagosome biogenesis in aged neurons.
    1. Cell Biology

    The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition

    Danielle DiTirro et al.
    A Tubby protein regulates ciliary membrane morphology and phosphoinositide composition in a context-dependent manner.
    1. Developmental Biology

    Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival

    Marshall Lukacs et al.
    Anchoring of proteins to the cell membrane through the glycosylphosphatidylinositol (GPI) anchor is critical for the survival of the cells that will give rise to the brain and face.
    1. Computational and Systems Biology

    Metabolic network percolation quantifies biosynthetic capabilities across the human oral microbiome

    David B Bernstein et al.
    A novel metabolic network analysis method enables large-scale computational predictions of biosynthetic capabilities across the human oral microbiome, revealing a unique cluster of fastidious microorganisms and potential metabolic interdependencies.

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