160 results found
    1. Developmental Biology
    2. Neuroscience

    Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures

    Yanshu Wang et al.
    Elevating beta-catenin signaling converts endothelial cells in typically fenestrated central nervous system vasculature to a blood-brain barrier (BBB) phenotype and promotes a BBB gene expression program and chromatin landscape.
    1. Developmental Biology
    2. Evolutionary Biology

    Bichir external gills arise via heterochronic shift that accelerates hyoid arch development

    Jan Stundl et al.
    Unique heterochrony in the cranial segments in bichirs triggers the early formation of their external gills, and might be informative about developmental mechanisms facilitating increased breathing capacity.
    1. Cancer Biology
    2. Human Biology and Medicine

    Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition

    Andrew L Hong et al.
    Faithful models of RMC require SMARCB1 loss for survival, and genetic and small-molecule screens identify inhibition of the ubiquitin-proteasome system (UPS) as a potential therapeutic approach for SMARCB1 deficient cancers.
    1. Computational and Systems Biology
    2. Developmental Biology

    Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells

    Idse Heemskerk et al.
    Live cell imaging demonstrates that the dynamics of ligand presentation influence signaling through two closely related morphogen signaling pathways in dramatically different ways.
    1. Computational and Systems Biology
    2. Developmental Biology

    Motion sensing superpixels (MOSES) is a systematic computational framework to quantify and discover cellular motion phenotypes

    Felix Y Zhou et al.
    A new computational framework provides a flexible and general approach for single and collective biological motion characterisation and phenotyping ideally suited for high-throughput timelapse screens.
    1. Developmental Biology

    Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification

    Rodrigo M Young et al.
    Disruptions to eye field size have little impact on final eye size due to tissue compensatory mechanisms.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Spatial and temporal organization of RecA in the Escherichia coli DNA-damage response

    Harshad Ghodke et al.
    Phase separated DNA-free stored forms of RecA dissolve in response to DNA damage to make RecA available for repair and recombination reactions as part of the bacterial (Escherichia coli) SOS response.
    1. Ecology
    2. Evolutionary Biology

    Molecular basis of wax-based color change and UV reflection in dragonflies

    Ryo Futahashi et al.
    UV-reflective dragonfly wax is shown to consist of very long-chain methyl ketones and aldehydes, and a synthetic dragonfly wax spontaneously forms light-scattering fine structures with strong UV reflection.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Individual long non-coding RNAs have no overt functions in zebrafish embryogenesis, viability and fertility

    Mehdi Goudarzi et al.
    Defining the biological functions of long non-coding RNAs, individually or as a class, and teasing apart the role of underlying genomic sequences remains the biggest challenge for this field.
    1. Developmental Biology

    Unique morphogenetic signatures define mammalian neck muscles and associated connective tissues

    Eglantine Heude et al.
    Genetic studies in the mouse provide a blueprint of the embryonic origins of neck muscles originating from cranial and somitic mesoderm, as well as associated connective tissue.

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