216 results found
    1. Cell Biology
    2. Neuroscience

    KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring

    Noriko Homma et al.
    Postnatal KIF2A is a key regulator for axon/dendrite determination of developing dentate granule cells, and its loss developed apical axons in dentate molecular layer, broke hippocampal wiring, and induced temporal lobe epilepsy.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Cleavage activates Dispatched for Sonic Hedgehog ligand release

    Daniel P Stewart et al.
    Dispatched cleavage, mediated by Furin, regulates Dispatched membrane trafficking and release of Sonic Hedgehog ligand.
    1. Developmental Biology and Stem Cells

    Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at naïve state

    Yixuan Wang et al.
    During reprogramming of human fibroblasts to naïve iPSCs there is transient reactivation of transcripts with the characteristics of 8-cell-stage-embryos.
    1. Developmental Biology and Stem Cells

    Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

    Sophie M Morgani et al.
    Micropatterned differentiation of mouse pluripotent stem cells gives rise to regionally distinct cell types arising in embryos at gastrulation.
    1. Developmental Biology and Stem Cells

    Developmental evolution of the forebrain in cavefish, from natural variations in neuropeptides to behavior

    Alexandre Alié et al.
    A comparative approach shows that developmental evolution of neuropeptidergic neuronal groups in the hypothalamus of blind cavefish drives adaptive behavioral evolution.
    1. Neuroscience

    Neuronal populations in the occipital cortex of the blind synchronize to the temporal dynamics of speech

    Markus Johannes Van Ackeren et al.
    Blind people re-purpose the brain's visual areas for tracking speech rhythm.
    1. Cell Biology

    Endosomal Rab cycles regulate Parkin-mediated mitophagy

    Koji Yamano et al.
    Parkin ubiquitination of damaged mitochondria recruits the Rab GEF, RABGEF1, to regulate downstream Rab cycles and ATG9A recruitment to growing phagophores that are participating in mitophagy.
    1. Neuroscience

    A postsynaptic PI3K-cII dependent signaling controller for presynaptic homeostatic plasticity

    Anna G Hauswirth et al.
    A screen encompassing all kinases and phosphatases reveals that PI3K-cII, PI3K-cIII and Rab11-dependent recycling endosomes comprise a novel, postsynaptic 'signaling controller' that is part of an integrated, trans-synaptic signaling system necessary for presynaptic homeostatic plasticity.
    1. Computational and Systems Biology

    The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture

    Athma A Pai et al.
    Surprising connections between gene architecture and splicing kinetics are illuminated using short, progressive metabolic labeling/RNA sequencing and novel computational modeling approaches in Drosophila cells.
    1. Developmental Biology and Stem Cells

    Distinct SoxB1 networks are required for naïve and primed pluripotency

    Andrea Corsinotti et al.
    Genetic manipulations show that endogenous transcription factors of the SoxB1 class act redundantly to maintain primed pluripotency and reveal differential effects on transitions between pluripotent and differentiation states.

Refine your results by:

Type
Research categories