12,831 results found
    1. Biochemistry and Chemical Biology

    Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

    Matthijs Kol, Ben Williams ... James A Frank
    Photoswitchable ceramides containing an azobenzene photoswitch behave as light-controllable substrates for both sphingomyelin synthase and glucosylceramide synthase.
    1. Cancer Biology

    ZHX2 promotes HIF1α oncogenic signaling in triple-negative breast cancer

    Wentong Fang, Chengheng Liao ... Qing Zhang
    ZHX2 controls HIF1α oncogenic signaling and tumorigenesis in triple-negative breast cancer.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case–control study

    Gemma Moncunill, Jason Carnes ... Raphael Gottardo
    Prevaccination levels of transcriptional modules related to monocytes, dendritic cells, and other immune categories correlate with clinical malaria risk in RTS,S/AS01E-vaccinated African children, suggesting that certain monocyte subsets may inhibit RTS,S/AS01E-induced protective responses.
    1. Cell Biology
    2. Developmental Biology

    Super-resolution microscopy reveals coupling between mammalian centriole subdistal appendages and distal appendages

    Weng Man Chong, Won-Jing Wang ... Jung-Chi Liao
    Super-resolved architectural framework of subdistal appendages surprisingly reveals coupling between distal appendages and subdistal appendages.
    1. Neuroscience

    Instantaneous movement-unrelated midbrain activity modifies ongoing eye movements

    Antimo Buonocore, Xiaoguang Tian ... Ziad M Hafed
    Sensory activity within the superior colliculus is read out by downstream motor structures and contributes to individual saccade kinematics with single spike precision.
    1. Neuroscience

    Brain-wide analysis of the supraspinal connectome reveals anatomical correlates to functional recovery after spinal injury

    Zimei Wang, Adam Romanski ... Murray G Blackmore
    Three-dimensional imaging and automated, brain-wide cell counting yield new insight into the diversity of neurons that connect the brain to the spinal cord and their different sensitivity to spinal cord damage.
    1. Neuroscience

    Awake responses suggest inefficient dense coding in the mouse retina

    Tom Boissonnet, Matteo Tripodi, Hiroki Asari
    Retinal visual response properties in awake mice are similar to those under anesthesia or ex vivo, but not exactly the same, so knowledge of retinal function cannot be simply translated from ex vivo to in vivo.
    1. Cell Biology
    2. Medicine

    Adipocyte NR1D1 dictates adipose tissue expansion during obesity

    Ann Louise Hunter, Charlotte E Pelekanou ... David A Bechtold
    Clock protein NR1D1 regulates white adipose tissue expansion and development of obesity-related pathology.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    A new role for histone demethylases in the maintenance of plant genome integrity

    Javier Antunez-Sanchez, Matthew Naish ... Jose Gutierrez-Marcos
    Plants reset chromatin marks during sexual reproduction to safeguard the stability of the genome.
    1. Neuroscience

    Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2

    Silvia Leon, Rajae Talbi ... Víctor M Navarro
    The transcription factor Nhlh2 is a marker of arcuate Kiss1 neurons in adulthood that activates the promotor activity of Kiss1 and Tac3 genes and controls puberty onset and the response of KNDy neurons to leptin in male mice.

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