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Biochemistry and Chemical Biology
O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals
Shogo Sawaguchi et al.
The transfer of O-GlcNAc by EOGT to specific EGF repeats of NOTCH1 promotes DLL4 binding, Notch signaling, and retinal vascular development.
Ubiquitylation-independent activation of Notch signalling by Delta
Nicole Berndt et al.
Analysis of a variant without lysine in the intracellular domain reveals a ubiquitylation-independent signalling activity of the DSL ligand Delta and novel functions of the Neuralized and Mindbomb1 E3-ligases during Notch signalling.
MPDZ promotes DLL4-induced Notch signaling during angiogenesis
Fabian Tetzlaff et al.
The multiple PDZ domain protein recruits Notch ligands to Nectin-2, which increases Notch signaling activity during angiogenesis.
Muscle contraction is required to maintain the pool of muscle progenitors via YAP and NOTCH during fetal myogenesis
Joana Esteves de Lima et al.
A novel mechanism links mechanical signals with the molecular YAP and NOTCH signals operating during developmental myogenesis.
The Notch-mediated hyperplasia circuitry in
reveals a Src-JNK signaling axis
Diana M Ho et al.
A diverse group of modifier genes, including the proto-oncogene Src, cooperate with Notch specifically to control cell proliferation.
Fringe proteins modulate Notch-ligand
interactions to specify signaling states
Lauren LeBon et al.
Fringe proteins modulate cis inhibitory, same-cell interactions between the Notch receptor and its ligands to control whether, and in which direction, cells can signal to one another.
LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in
Pengpeng Li et al.
The Notch signaling pathway has a central role in the formation of the circuit that controls egg-laying in the nematode worm
Stage-specific effects of Notch activation during skeletal myogenesis
Pengpeng Bi et al.
While Notch activation dedifferentiates newly differentiated muscle cells; it improves the function of muscle fiber as a niche-supporting cell of muscle stem cells.
The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro
Lena Tveriakhina et al.
Regions outside the major receptor binding interface of DLL1 and DLL4 contribute to context-dependent divergence of ligand function in vivo and differential Notch1 and Notch2 activation in vitro.
Muscle niche-driven Insulin-Notch-Myc cascade reactivates dormant Adult Muscle Precursors in
Rajaguru Aradhya et al.
Adult muscle precursors (AMP) cells in
send out filopodia to interact with neighbouring muscles, which drive the reactivation of AMPs via an Insulin-Notch-Myc cascade.
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