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    1. Genetics and Genomics
    2. Computational and Systems Biology

    Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expression

    Jie Lin, Yujian Wen ... Hao Zhu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Neuroscience

    A multiplex of connectome trajectories enables several connectivity patterns in parallel

    Parham Mostame, Jonathan Wirsich ... Sepideh Sadaghiani
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Neuroscience
    2. Physics of Living Systems

    A Deep Learning Pipeline for Mapping in situ Network-level Neurovascular Coupling in Multi-photon Fluorescence Microscopy

    Matthew Rozak, James Mester ... Bojana Stefanovic
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Incomplete
    1. Neuroscience

    Parahippocampal neurons encode task-relevant information for goal-directed navigation

    Alexander Gonzalez, Lisa M Giocomo
    Parahippocampal neurons increase their activity rates following navigational errors, and the error signal magnitude is related with overall task performance.
    1. Genetics and Genomics

    Reprogramming of translation in yeast cells impaired for ribosome recycling favors short, efficiently translated mRNAs

    Swati Gaikwad, Fardin Ghobakhlou ... Alan G Hinnebusch
    A mutant impaired for ribosome recycling exhibits translational reprogramming wherein strong mRNAs outcompete weak mRNAs, also observed when preinitiation complexes are diminished by eIF2α phosphorylation or 40S ribosomal subunit depletion.
    1. Microbiology and Infectious Disease

    A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture

    Clare Andradi-Brown, Jan Stephan Wichers-Misterek ... Anna Bachmann
    An enhanced bioinformatic pipeline to quantify Plasmodium falciparum core gene and polymorphic var gene expression revealed changes occurring during early culture adaptation of parasites from naturally infected individuals.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery

    Viviane Kremling, Sven Falke ... Janina Sprenger
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Treacle’s ability to form liquid phase condensates is essential for nucleolar fibrillar center assembly, efficient rRNA transcription and processing, and rRNA gene repair

    Artem K Velichko, Anastasia P Kovina ... Omar L Kantidze
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Genetics and Genomics
    2. Evolutionary Biology

    Refining the resolution of the yeast genotype-phenotype map using single-cell RNA-sequencing

    Arnaud N’Guessan, Wen Yuan Tong ... Alex N Nguyen Ba
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Convincing
    1. Computational and Systems Biology

    Pseudo-grading of tumor subpopulations from single-cell transcriptomic data using Phenotype Algebra

    Namrata Bhattacharya, Anja Rockstroh ... Debarka Sengupta
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
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