Single-cell transcriptomics of the zebrafish ovary identifies both major and minor cell types and provides a valuable resource for researchers interested in reproductive biology, stem cell biology, and aquatic toxicology.
Predicted gene regulatory networks active in planarians adult stem cells provide testable hypotheses about the control of pluripotency and differentiation in animals.
The use of forward genetic screens in zebrafish identifies a new model of vertebrate aging, defining the regulating of the onset of aging phenotypes through maintenance of progenitor cell populations.
A novel in vivo strategy for reversible, multiplexed control of circulating hormone expression levels, achieved by combining genome-editing and intramuscular electroporation of fluorescently tagged hormones in the naturally short-lived turquoise killifish.
An automated feeding system to precisely control feeding in the killifish opens new areas to explore vertebrate lifespan, cognitive decline, dietary interventions, and drug screening in a high-throughput manner.
Rapid and efficient CRISPR/Cas9-mediated knock-in of fluorescent reporters at various genomic loci enables cell- and tissue-specific expression and establishes the short-lived African killifish as a vertebrate system for precise genetic engineering at scale.
William John Bradshaw, Michael Poeschla ... Dario Riccardo Valenzano
Naturally short-lived turquoise killifish undergo systemic and mucosal spontaneous decline in antibody-repertoire diversity during aging, recapitulating in a few months the aging-dependent decline of adaptive immunity.
Johannes Krug, Birgit Perner ... Christoph Englert
Using the short-lived turquoise killifish, a transparent in vivo reporter line named klara is established that will be a valuable tool to explore development, senescence, aging, and regeneration.
