44 results found
    1. Neuroscience

    Corticothalamic gating of population auditory thalamocortical transmission in mouse

    Baher A Ibrahim et al.
    Sensory stimulation produces stochastic population responses in the cortex that are governed by layer 6 cortico-reticular projections that modulate thalamic synchrony.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae

    André Heuer et al.
    Near atomic resolution of late 40S ribosomal subunit assembly by cryo-EM reveals immature rRNA active sites stabilized by biogenesis factors.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction

    Jean-Baptiste Fourmann et al.
    Prp43 binds to the pre-mRNA and contacts predominantly U2 proteins in the budding yeast spliceosome.
    1. Neuroscience

    Parallel pathways for sound processing and functional connectivity among layer 5 and 6 auditory corticofugal neurons

    Ross S Williamson, Daniel B Polley
    Targeted recordings from subcortical projection neurons in the auditory cortex reveal two cell classes with distinct signatures of sensory processing and different patterns of local and long-range connectivity.
    1. Structural Biology and Molecular Biophysics

    Molecular architecture of the 90S small subunit pre-ribosome

    Qi Sun et al.
    The nearly complete architecture of the gigantic 90S precursor of small ribosomal subunit is determined by cryo-EM.
    1. Neuroscience

    Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex

    Stephanie C Seeman et al.
    A high-throughput pipeline for the characterization of cortical connectivity in mouse and human cortex.
    1. Genetics and Genomics

    Cohesin residency determines chromatin loop patterns

    Lorenzo Costantino et al.
    High-resolution mapping of cohesin-dependent chromatin loops in the genome of budding yeast reveals evolutionarily conserved features for loop formation and cohesin residency as a determinant of loop positioning.
    1. Neuroscience

    A projection specific logic to sampling visual inputs in mouse superior colliculus

    Katja Reinhard et al.
    Transsynaptic viral tracing reveals that neurons in the superior colliculus employ projection specific rules to the sampling of retinal inputs, directing distinct visual features to different downstream targets.
    1. Biochemistry and Chemical Biology

    Prefabrication of a ribosomal protein subcomplex essential for eukaryotic ribosome formation

    Cohue Peña et al.
    The ATPase Fap7 prefabricates a uS11:eS26 ribosomal protein complex for ribosome assembly.
    1. Neuroscience

    VIP interneurons in mouse primary visual cortex selectively enhance responses to weak but specific stimuli

    Daniel J Millman et al.
    Measurements of visual response to motion of different contrasts along with network modeling reveals a microcircuit in superficial layers of cortex that regulates the gain regime.

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