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    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Protein kinase C coordinates histone H3 phosphorylation and acetylation

    Zoulfia Darieva et al.
    Chromatin structure is altered following DNA replication stress through the activity of protein kinase C signalling which leads to functionally coupled histone H3 phosphorylation and acetylation events.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

    Patrick Laurette et al.
    The PBAF chromatin-remodelling complex is essential for the proliferation of melanocytes and melanoma cells and is recruited to critical regulatory elements by physical and functional interactions with MITF, a transcription factor and master regulator of melanoma.
    1. Microbiology and Infectious Disease

    Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch

    Benjamin Rauwel et al.
    Inactivation of KAP1 by mTOR-mediated phosphorylation releases human cytomegalovirus from latency, and has the potential to be used as a therapy to purge the virus from transplant organs.
    1. Immunology and Inflammation

    A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model

    Yasunobu Arima et al.
    Pain sensation induces relapse in a mouse model of multiple sclerosis via a sensory-sympathetic signaling pathway.
    1. Chromosomes and Gene Expression

    YTH-RNA-binding protein prevents deleterious expression of meiotic proteins by tethering their mRNAs to nuclear foci

    Yuichi Shichino et al.
    A YTH-domain protein Mmi1 prevents deleterious expression of meiotic proteins by tethering their mRNAs to nuclear foci.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking

    Bo Li et al.
    The retromer complex serves as a bomb squad to retrieve and disarm the potentially harmful pool of Notch receptors in a timely manner and thereby safeguards against brain tumor formation.
    1. Cell Biology
    2. Neuroscience

    Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104

    Jiaxing Li et al.
    Synaptic defects previously attributed to loss of kinesin function are found to be mediated by the Wnd/DLK axonal injury signaling pathway, which restrains the total levels of presynaptic proteins in response to their accumulation.
    1. Neuroscience

    Pretectal neurons control hunting behaviour

    Paride Antinucci et al.
    A discrete population of genetically accessible pretectal neurons controls visually guided hunting behaviour in larval zebrafish.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    The DREAM complex through its subunit Lin37 cooperates with Rb to initiate quiescence

    Christina FS Mages et al.
    Lin37 is essential for cell-cycle gene repression by the DREAM complex in cellular quiescence and a combined loss of Lin37 and Rb prevents cell-cycle exit in response to growth-limiting signals.
    1. Cell Biology
    2. Evolutionary Biology

    A unicellular relative of animals generates a layer of polarized cells by actomyosin-dependent cellularization

    Omaya Dudin et al.
    Cellularization in Sphaeroforma arctica generates a self-organized structure that morphologically resembles an epithelium, and is associated with tightly regulated expression of cell adhesion pathways.