12 results found
    1. Cell Biology

    Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5

    Illyce Nuñez, Marbelys Rodriguez Pino ... Fulvia Verde
    NDR kinase Orb6 prevents RNP granule assembly and translational repression by promoting Sts5 association with 14-3-3 protein Rad24 to spatially control polarized cell growth.
    1. Developmental Biology

    YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis

    Chuwen Lin, Erica Yao ... Pao-Tien Chuang
    The control of local cell properties such as epithelial cell number and mechanical force production by Hippo signaling is a major determinant of lung branching.
    1. Developmental Biology

    Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1

    David Kimelman, Natalie L Smith ... Didier YR Stainier
    Analysis of a double mutant in the Hippo pathway transcription factors Yap1 and Wwtr1 reveals novel roles for these factors in posterior body formation and epidermal morphogenesis in the vertebrate embryo.
    1. Neuroscience

    LKB1 coordinates neurite remodeling to drive synapse layer emergence in the outer retina

    Courtney A Burger, Jonathan Alevy ... Melanie A Samuel
    LKB1 instructs the timing and location of synapse layer emergence in the outer retina by coordinating the regulation of pre- and postsynaptic neuron maturation and transport of synapse-associated proteins.
    1. Cell Biology
    2. Developmental Biology

    Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure

    Eric R Brooks, Mohammed Tarek Islam ... Jennifer A Zallen
    Closure of the cranial neural tube, which is essential for mammalian development, is driven by spatially and temporally patterned cell remodeling events that require positionally regulated Sonic hedgehog signaling.
    1. Chromosomes and Gene Expression

    Yeast Nuak1 phosphorylates histone H3 threonine 11 in low glucose stress by the cooperation of AMPK and CK2 signaling

    Seunghee Oh, Jaehyoun Lee ... Jerry L Workman
    Yeast Nuak1 is an AMPK and CK2 dependent H3 T11 kinase.
    1. Cell Biology

    Pak1 kinase controls cell shape through ribonucleoprotein granules

    Joseph O Magliozzi, James B Moseley
    A newly discovered substrate of Pak1 kinase reveals novel mechanisms that control cell shape through regulated assembly of ribonucleoprotein granules.
    1. Biochemistry and Chemical Biology

    Redox Regulation of Brain Selective Kinases BRSK1/2: Implications for Dynamic Control of the Eukaryotic AMPK family through Cys-based mechanisms

    George N. Bendzunas, Dominic P Byrne ... Natarajan Kannan
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Convincing
    1. Cell Biology

    Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

    Devon E. Mason, Paula Camacho ... Joel D. Boerckel
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology

    Human receptive endometrial organoid for deciphering the implantation window

    Yu Zhang, Rusong Zhao ... Han Zhao
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete

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