Hantaan virus nucleocapsid cryo-EM structure determined at 3.3 Å resolution reveals how nucleoproteins assemble into a metastable helix containing a continuous RNA-binding groove compatible with genome encapsidation and compaction.

Structural and functional studies reveal how Newcastle disease virus nucleocapsid protects its viral genome through a self-capping mechanism, which is important for new antiviral drug design.

A structural comparison of different states of the protein responsible for encapsidation of the viral RNA genome provides mechanistic insights into this process.

Exploration of the phenotype space corresponding to the sequence space of viable SARS-CoV-2 nucleocapsid protein species reveals significant diversity of biophysical characteristics, nonlocal mutation effects, and functional constraints.

SARS-CoV-2 host-shutoff inhibits innate NK surveillance by suppressing activating ligands, however ADCC provides a potent NK stimulus that is mediated by antibodies targeting Nucleocapsid, ORF3a, and Membrane, with those targeting Spike being significantly weaker.

The BNT162b2 mRNA COVID-19 vaccine is highly effective at generating immune responses in people over the age of 80 years and provides good cross neutralization of the P.1 gamma variant of concern.

Exploring how UBQLN2 mutations cause ALS leads to the discovery of a pathway by which an ancient retroelement changes gene expression in human cells.

Initiation of the assembly of HIV-1 particles in infected cells is required to form a subviral structure that recognizes the viral RNA genome for packaging.

A new study reveals how naturally occurring mutations affect the biophysical properties of nucleocapsid proteins in SARS-CoV-2.

A combination of X-ray crystallography, molecular dynamics and small angle X-ray scattering shows that the transcription antiterminator M2-1 is a structurally dynamic homotetramer that undergoes large concerted conformational changes upon binding its target RNA.