New reconstruction methods are used to create a publicly available dense reconstruction of the neurons and chemical synapses of central brain of Drosophila, with analysis of its graph properties.

Comprehensive characterization of kinase-dependent phosphorylation in the human pathogen Toxoplasma gondii identifies a trafficking adaptor complex required for virulence factor secretion and infection.

AAV-Txnip prolongs vision in mouse models of blindness, enhancing lactate catabolism, mitochondrial health, and ATP production in a condition that likely has a limited glucose supply.

The development of complex motion processing in higher-level visual cortex involves functional changes in primary visual cortex, indicating coordinated development in multiple nodes of the visual hierarchy.

Complexes formed by calcium- and integrin-binding proteins 2 and 3 and transmembrane channel-like proteins 1 and 2 are essential for vertebrate hearing and balance and for fish lateral line function.

Genome-wide analyses reveal how tumor-associated mutations of the Fbw7 ubiquitin ligase impact oncogenic transcription factors and gene expression.

Analysis of the mechanism of action of cystic fibrosis corrector drugs reveals signalling pathways potently controlling the proteostasis of the main disease-relevant CFTR mutant.