The novel live-attenuated SARS-CoV-2 nasal vaccine candidate is highly safe, induces robust cellular and mucosal immunity, and generates long-lasting neutralizing antibody titers.

Low estrogen levels in postmenopausal hypertension are linked to metabolic reprogramming and aortic tissue changes, with L-alpha-aminobutyric acid emerging as a potential protective biomarker.

Evidence is provided suggesting that heterochromatin re-organisation during cell senescence can compromise the structural integrity of the nucleus, leading to activation of an inflammatory process.

RNA processing genes regulated during sleep-dependent memory may contribute to sleep and memory.

Degradation products of polysaccharides trigger partial population dispersal and alter cellular metabolism, shaping the marine biomass decomposition by foraging bacteria.

The three-dimensional architecture of the genome in distinct cell types predicts genes and regulatory elements involved in cell function and disease.

Proximity labeling combined with mass spectrometry enables to map the proteasome proximal proteome in cells and mouse tissues.