43 results found
    1. Neuroscience

    Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex

    Raphael M Bendriem et al.
    That early cortical neural progenitor divisions strictly require OCLN isoform expression is a paradigm shift in the functional consideration of this protein best known for promoting between-cell barrier functions.
    1. Cell Biology
    2. Immunology and Inflammation

    Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1

    Maria-Bernadette Madel et al.
    Osteoclasts emerging in inflammation are heterogeneous and encompass a strongly inflammatory subset with a high resorbing activity and an immune suppressive subset that are able to control each other.
    1. Biochemistry and Chemical Biology
    2. Medicine

    The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

    Omar Al Rifai et al.
    In mice, but not in humans, the bone-derived hormone osteocalcin is O-glycosylated, a post-translational modification controlling its half-life in vivo.
    1. Cell Biology

    The mechanosensitive Piezo1 channel is required for bone formation

    Weijia Sun et al.
    Piezo1 functions as a key mechanotransducer for conferring mechanosensitivity to osteoblasts and determining mechanical-load-dependent bone formation, and represents a novel therapeutic target for treating osteoporosis or unloading-induced severe bone loss.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Decoding the centromeric nucleosome through CENP-N

    Satyakrishna Pentakota et al.
    A comprehensive structural, biochemical, and cell biological analysis reveals the molecular mechanism and significance of the conserved interaction of centromeric protein N (CENP-N) with the centromeric nucleosome.
    1. Developmental Biology

    Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice

    Fabienne Benz et al.
    Endothelial tightening by augmenting low level Wnt/β-catenin activity in vessels of the mouse subfornical organ, influences neuronal activation in water-deprived mice, linking endothelial barrier properties to neuro-vascular coupling.
    1. Cell Biology

    Homeostatic control of START through negative feedback between Cln3-Cdk1 and Rim15/Greatwall kinase in budding yeast

    Nicolas Talarek et al.
    Inhibition of phosphatases by kinases develops Whi5 phosphorylation and cell cycle function in low cyclin-dependent kinase activity.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi

    Edgar M Medina et al.
    Cell cycle network evolution in a fungal ancestor was punctuated by the arrival of a viral DNA-binding protein that was permanently incorporated into the regulatory network controlling cell cycle entry.
    1. Biochemistry and Chemical Biology

    Inter-membrane association of the Sec and BAM translocons for bacterial outer-membrane biogenesis

    Sara Alvira et al.
    The protein translocation apparatus of the inner- (Sec) and outer-membrane (BAM) interact to form a trans-periplasmic super-complex capable of long-range, PMF-dependent conformational changes to facilitate efficient outer-membrane protein maturation.
    1. Cancer Biology
    2. Immunology and Inflammation

    Osterix-Cre marks distinct subsets of CD45- and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics

    Biancamaria Ricci et al.
    Osterix, a transcription factor regulating osteoblast differentiation and bone formation, is expressed in subsets of CAFs with osteogenic features and marks tumor infiltrating immune populations enriched in immune suppressive markers.

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