5,379 results found
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments

    Michal Barski et al.
    Insight into the molecular assembly of a protein with a central role in infections paves the way to understanding how Rift Valley fever virus causes disease.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for the recognition of spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in splicing regulation

    André Mourão et al.
    Interactions with Sm proteins can provide a way in which regulatory factors can modulate alternative splice site choices.
    1. Structural Biology and Molecular Biophysics

    The complete structure of the human TFIIH core complex

    Basil J Greber et al.
    The structure of human transcription factor IIH, a critical DNA repair and transcription initiation factor, has been determined by cryo-electron microscopy.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    CryoEM and computer simulations reveal a novel kinase conformational switch in bacterial chemotaxis signaling

    C Keith Cassidy et al.
    An atomic model of the bacterial chemosensory array obtained through the synthesis of cryo-electron tomography and large-scale molecular-dynamics simulations reveals a new kinase conformation during signaling events.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1

    Xiaofei Jia et al.
    HIV-1 viral protein u (Vpu) can stimulate novel versions of canonical interactions with the clathrin adaptor AP1 to counteract the host antiviral protein BST2.
    1. Structural Biology and Molecular Biophysics

    Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability

    Cihan Makbul et al.
    Duck Hepatitis B core protein forms capsids with a slowly folding extension domain which folding competence is important for viral replication.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis

    Shaogeng Tang et al.
    Building on previous work (Tang et al., 2015), novel ESCRT-III subunit Snf7 auto-activation mutants are used to reveal two parallel ubiquitin-dependent pathways during multivesicular endosome biogenesis.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver

    Bryan J Matthews, David J Waxman
    Certain types of 3D chromatin loops are easy to predict from existing or easily obtainable 2D information, which benefits gene expression studies in tissues/cells/organisms without extensive pre-existing 3D information.
    1. Structural Biology and Molecular Biophysics

    Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core

    Andrew J Borst et al.
    An integrative structural and biophysical workflow indicates engagement of VRC01 germline antibodies can occur with a gp120 426c core construct containing all wild-type N-linked glycosylation sites, including the Asn276 glycan.
    1. Structural Biology and Molecular Biophysics

    Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5′ splice site recognition

    Yasushi Kondo et al.
    The complete architecture of human spliceosomal U1 snRNP and its interaction with the 5′ splice site of pre-mRNA are described in atomic detail.

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