54 results found
    1. Cell Biology
    2. Developmental Biology

    Super-resolution microscopy reveals coupling between mammalian centriole subdistal appendages and distal appendages

    Weng Man Chong et al.
    Super-resolved architectural framework of subdistal appendages surprisingly reveals coupling between distal appendages and subdistal appendages.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Dissection of affinity captured LINE-1 macromolecular complexes

    Martin S Taylor et al.
    The range of molecular forms adopted by L1 retrotransposons reflect a tapestry of lifecycle-permissive and -restrictive host-parasite interactions occurring within cells.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    BET family members Bdf1/2 modulate global transcription initiation and elongation in Saccharomyces cerevisiae

    Rafal Donczew, Steven Hahn
    Yeast bromodomain-containing factors Bdf1/2 offer insights into the biological role of the BET family of transcriptional regulators, which is a promising target in cancer therapy.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Chromatin signature of widespread monoallelic expression

    Anwesha Nag et al.
    Active and repressive chromatin marks, asymmetrically distributed between alleles, distinguish gene bodies subject to epigenetically controlled monoallelic expression on autosomes in human cells.
    1. Stem Cells and Regenerative Medicine
    2. Genetics and Genomics

    Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells

    Marie MacLennan et al.
    Post-translational regulation of retrotransposons plays a key role in preventing retrotransposon mobilization in the epigenetically dynamic mouse germline.
    1. Cell Biology

    LINE-1 protein localization and functional dynamics during the cell cycle

    Paolo Mita et al.
    A combination of functional, biochemical and imaging studies show that LINE-1/L1 proteins and mRNA enter the nucleus through mitotic nuclear membrane breakdown, interact with components of the DNA replication fork and mediate retrotransposition during S phase.
    1. Genetics and Genomics
    2. Neuroscience

    Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function

    Sonia Coni et al.
    A decrease of the type 2 myotonic dystrophy gene product CNBP causes an impairment of polyamine metabolism and locomotor dysfunction that can be reverted with polyamine supplementation.
    1. Genetics and Genomics

    Expansion of the circadian transcriptome in Brassica rapa and genome-wide diversification of paralog expression patterns

    Kathleen Greenham et al.
    Whole genome duplication in Brassica rapa is accompanied by both expansion of the circadian transcriptome and widespread temporal reconfiguration of gene regulatory networks consistent with subfunctionalization among pairs of paralogs.
    1. Computational and Systems Biology

    A large accessory protein interactome is rewired across environments

    Zhimin Liu et al.
    A massively multiplexed multi-condition screen shows that protein interactomes are larger than previously thought and contain highly dynamic regions that reorganize to drive or respond to cellular changes.
    1. Neuroscience

    A causal relationship between face-patch activity and face-detection behavior

    Srivatsun Sadagopan et al.
    Disrupting the activity of the medial lateral face patch (ML) using fMRI-targeted microinjections of muscimol leads to anatomically and categorically specific impairments in a naturalistic face detection task.

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