936 results found
    1. Microbiology and Infectious Disease

    RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies

    Fiona Tulloch et al.
    Attenuating candidate live virus vaccines by incorporating unfavoured codon pairs to reduce translation efficiency is actually mediated though changes in frequencies of CpG and UpA dinucleotides, which make viruses more visible to the innate immune system.
    1. Biochemistry and Chemical Biology

    Cdc48-like protein of actinobacteria (Cpa) is a novel proteasome interactor in mycobacteria and related organisms

    Michal Ziemski et al.
    Cdc48-like protein of actinobacteria (Cpa) is a AAA+ proteasomal interactor involved in adaptation of mycobacteria to carbon limitation and potentially influencing ribosomal composition of the cell.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α+thalassaemia

    D Herbert Opi et al.
    Analysis of a large Kenyan dataset may resolve previously conflicting studies by identifying polymorphisms which interact to modify the risk of cerebral malaria.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes

    Masahiro Oka et al.
    Nup98-HoxA9 is recruited to Hox gene cluster regions together with the chromosomally pre-bound nuclear export factor Crm1, which induces aberrant expression of several Hox genes and affecting the differentiation of embryonic stem cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    An evidence based hypothesis on the existence of two pathways of mitochondrial crista formation

    Max E Harner et al.
    Lamellar and tubular cristae in mitochondria form by two different molecular pathways that form both involve F1FO-ATP synthase dimers and the MICOS complex, but formation of lamellar cristae also relies on Mgm1/Opa1.
    1. Ecology
    2. Evolutionary Biology

    Reproduction: Parasites opt for the best of both worlds

    Ellen Decaestecker, Lore Bulteel
    The fungal parasite Podosphaera plantaginis employs both sexual and asexual reproduction to increase its chances of infecting the plant Plantago lanceolata.
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    1. Microbiology and Infectious Disease

    The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

    Stephen Patterson et al.
    Biological and pharmacokinetic studies indicate that the anti-tubercular drug, delamanid, could be repurposed for the treatment of visceral leishmaniasis.
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology

    An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP

    Marc Fiedler et al.
    The Chip/LDB-SSDP complex integrates multiple signals to render TCF/LEF enhancers Wnt responsive.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    The mechanism of variability in transcription start site selection

    Libing Yu et al.
    Variability in bacterial transcription start site selection involves DNA “scrunching” and “anti-scrunching,” which may represent a general mechanism for start site selection in all organisms.
    1. Developmental Biology

    Quantification of gene expression patterns to reveal the origins of abnormal morphogenesis

    Neus Martínez-Abadías et al.
    Quantitative analyses associating the morphology of developing organs with dynamic gene expression patterns can reveal biological phenomena that cause malformations and malfunction but remain elusive to traditional qualitative assessments.

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