A key molecule that connects leukemogenic proteins to aberrant HOX gene regulation turned out to be a nuclear export factor, CRM1.

Nup98-HoxA9 is recruited to Hox gene cluster regions together with the chromosomally pre-bound nuclear export factor Crm1, which induces aberrant expression of several Hox genes and affecting the differentiation of embryonic stem cells.

The expression of Arabidopsis NLR immune response genes is modulated by premature transcription termination, and this has implications for understanding NLR regulation and evolutionary dynamics.

A honeycomb-lattice assembly within the skin and mucosa protects us from invading pathogens.

Time-resolved serial femtosecond crystallography revealed retinal kink and early changes in channelrhodopsin, which leads to the ion pore formation.

In a mouse model of DYT25 dystonia with disruption of striatal neurotransmission by Gnal mutation, the cerebello-thalamic excitability is increased following symptom expression and θ-burst cerebellar stimulations during cholinergic-induced dystonia depress the cerebello-thalamic transmission and reduce the motor symptom severity.

Cdc48-like protein of actinobacteria (Cpa) is a AAA+ proteasomal interactor involved in adaptation of mycobacteria to carbon limitation and potentially influencing ribosomal composition of the cell.

Deletion of optic atrophy 1 in brown adipose tissue induces secretion of growth differentiation factor 15 as a batokine to attenuate diet-induced obesity and improve glucose clearance, hepatic steatosis, and thermoregulation in mice by increasing energy expenditure.

Using a computational approach for designing object recognition tasks is beneficial to highlight the different strategies among different species.

GTP binding induces rearrangement of S-OPA1 assembly on membrane and thus triggers membrane remodeling with reduced curvature.