13 results found
    1. Cell Biology
    2. Genomics and Evolutionary Biology

    Retrotransposons: On the move

    Sandra L Martin
    The mechanisms by which a retrotransposon called LINE-1 duplicates itself and spreads through the human genome are becoming clearer.
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    1. Genomics and Evolutionary Biology
    2. Human Biology and Medicine

    APOBEC3A deaminates transiently exposed single-strand DNA during LINE-1 retrotransposition

    Sandra R Richardson et al.
    Combining in vitro and in vivo assays demonstrates that the cytidine deaminase APOBEC3A can inhibit LINE-1 retrotransposition by deaminating transiently exposed single-strand DNA that arises during the process of LINE-1 integration.
    1. Developmental Biology and Stem Cells
    2. Genomics and Evolutionary Biology

    Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells

    Marie MacLennan et al.
    Post-translational regulation of retrotransposons plays a key role in preventing retrotransposon mobilization in the epigenetically dynamic mouse germline.
    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome

    Yoong Wearn Lim et al.
    Global epigenetic perturbations and accumulation of RNA:DNA hybrids are two novel hallmarks of the lupus-like inflammatory disorder Aicardi-Goutières syndrome.
    1. Cell Biology
    2. Genomics and Evolutionary Biology

    LINE-1 protein localization and functional dynamics during the cell cycle

    Paolo Mita et al.
    A combination of functional, biochemical and imaging studies show that LINE-1/L1 proteins and mRNA enter the nucleus through mitotic nuclear membrane breakdown, interact with components of the DNA replication fork and mediate retrotransposition during S phase.
    1. Genes and Chromosomes

    Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation

    Oscar Velazquez Camacho et al.
    An RNA-mediated mechanism that stabilizes association of the Suv39h enzymes at mouse heterochromatin is defined.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Dissection of affinity captured LINE-1 macromolecular complexes

    Martin S Taylor et al.
    The range of molecular forms adopted by L1 retrotransposons reflect a tapestry of lifecycle-permissive and -restrictive host-parasite interactions occurring within cells.
    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress

    Alicia N McMurchy et al.
    Genome-wide profiling and functional analyses reveal a network of heterochromatin and small RNA factors that silences repetitive elements and prevents genotoxic stress to ensure fertility.
    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci

    Claude Philippe et al.
    The expression of human L1 retrotransposons is highly locus-specific and variable between different cell types.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural characterization of ribosome recruitment and translocation by type IV IRES

    Jason Murray et al.
    A Internal Ribosomal Entry Site RNA has been visualised by high resolution cryoEM, trapped in the ribosome in an intermediate state of translocation.

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