Origin recognition complex-associated (ORCA) is crucial for the stability of the Histone H3 lysine 9 methyltransferase megacomplex, which is essential for heterochromatin organization.

A family of proteins (OSCA/TMEM63) that encode mechanosensitive ion channels has been characterized in plants, flies, and mammals.

The cell surface receptor LRP4, long recognized for postsynaptic functions, also plays a role as a presynaptic determinant of synapse formation by functioning through a downstream kinase pathway.

A comprehensive synapse-level analysis of a fly central-brain region has led to the identification of molecules that are necessary for mediating the normal density of connections.

A text-mining study suggests that about half of the papers reporting the results of experiments on mice do not report the sex and age of the mice.

Cuttlefish embryos reveal that cephalopod mollusks evolved specialized arms and tentacles by activating the same genetic circuits that control development of limbs in arthropods and vertebrates.

Super-resolution imaging reveals a novel multi-channel arrangement that explains how big potassium (BK) channel activation closely tracks the opening of low-voltage-activated L-type calcium channels.

An RNA-mediated mechanism that stabilizes association of the Suv39h enzymes at mouse heterochromatin is defined.

The Chip/LDB-SSDP complex integrates multiple signals to render TCF/LEF enhancers Wnt responsive.

BCL9/Legless is an integral component of the Wnt enhanceosome, harboring binding sites in its conserved C-terminus for multiple core components of this complex including ChiLS and Groucho/TLE.