87 results found
    1. Microbiology and Infectious Disease

    Septal secretion of protein A in Staphylococcus aureus requires SecA and lipoteichoic acid synthesis

    Wenqi Yu et al.
    Surface protein precursors traffic to lipoteichoic acid-rich septal membranes of Staphylococcus aureus for cleavage of their YSIRK-GXXS motif signal peptides and SecA-mediated translocation across the plasma membrane.
    1. Neuroscience

    Cellular diversity in the Drosophila midbrain revealed by single-cell transcriptomics

    Vincent Croset et al.
    Sequencing mRNA from thousands of single cells from the Drosophila brain highlights the extent of cellular diversity and reveals co-expression of specific neuropeptides with particular fast-acting neurotransmitters and monoamines.
    1. Neuroscience

    Fast and accurate edge orientation processing during object manipulation

    J Andrew Pruszynski et al.
    Tactile edge orientation processing during object manipulation is many times better than previously thought based on perceptual studies.
    1. Neuroscience

    Drosophila mushroom bodies integrate hunger and satiety signals to control innate food-seeking behavior

    Chang-Hui Tsao et al.
    Mushroom bodies are a hunger and satiety integrative center that controls food-seeking behavior in Drosophila..
    1. Epidemiology and Global Health

    Conjunction of factors triggering waves of seasonal influenza

    Ishanu Chattopadhyay et al.
    Three complementary computational approaches reveal a set of putative causes of initiation of pan-USA waves of influenza.
    1. Neuroscience

    Salient experiences are represented by unique transcriptional signatures in the mouse brain

    Diptendu Mukherjee et al.
    Inducible transcription in the brain encodes detailed aspects of recent experience.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing

    Sabine Schürmann et al.
    Proteolysis of lipidated N-terminal peptides that tether Hedgehog morphogens to the surface of source cells is absolutely required for their coupled release and bioactivation in vivo in Drosophila melanogaster.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure

    Jieqiong Gao et al.
    The endosomal GEF Mon1-Ccz1 binds to Atg8 on autophagosomes, and recruits its substrate, the Rab7-like Ypt7, which then mediates fusion of the autophagosomes with the lysosome.
    1. Neuroscience

    A sleep state in Drosophila larvae required for neural stem cell proliferation

    Milan Szuperak et al.
    A role for sleep in developmental neurogenesis is revealed using a new system for studying sleep during nascent periods.
    1. Neuroscience

    LRRTM1 underlies synaptic convergence in visual thalamus

    Aboozar Monavarfeshani et al.
    The synaptic cell adhesion molecule, leucine-rich repeat transmembrane neuronal 1 (LRRTM1), plays an important role in the establishment of retinal convergence onto relay cells in mouse visual thalamus.

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