77 results found
    1. Developmental Biology and Stem Cells
    2. Genomics and Evolutionary Biology

    CRISPR/Cas9 and active genetics-based trans-species replacement of the endogenous Drosophila kni-L2 CRM reveals unexpected complexity

    Xiang-Ru Shannon Xu et al.
    Dissection of a cis-regulatory element (CRM) in its native chromosomal context using CRISPR/Cas9 editing and novel 'Active Genetics' reveals new features of CRM function and insights into how such regulatory elements change during evolution.
    1. Cell Biology

    Endosomal Rab cycles regulate Parkin-mediated mitophagy

    Koji Yamano et al.
    Parkin ubiquitination of damaged mitochondria recruits the Rab GEF, RABGEF1, to regulate downstream Rab cycles and ATG9A recruitment to growing phagophores that are participating in mitophagy.
    1. Developmental Biology and Stem Cells

    The zinc-finger transcription factor Hindsight regulates ovulation competency of Drosophila follicles

    Lylah D Deady et al.
    Hindsight/RREB-1 plays a conserved role in follicle maturation and ovulation by sequential upregulation of matrix metalloproteinase and adrenergic receptor in follicle cells.
    1. Cell Biology

    Atg9 antagonizes TOR signaling to regulate intestinal cell growth and epithelial homeostasis in Drosophila

    Jung-Kun Wen et al.
    Atg9 inhibits TOR signaling to regulate cell growth and tissue homeostasis in Drosophila adult midgut.
    1. Ecology
    2. Human Biology and Medicine

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
    1. Biochemistry and Chemical Biology
    2. Biophysics and Structural Biology

    AMPylation targets the rate-limiting step of BiP’s ATPase cycle for its functional inactivation

    Steffen Preissler et al.
    AMPylation of BiP allosterically interferes with stimulation of its ATPase activity by J-proteins that is required for high affinity substrate binding.
    1. Biophysics and Structural Biology

    Allosteric fine-tuning of the conformational equilibrium poises the chaperone BiP for post-translational regulation

    Lukasz Wieteska et al.
    The molecular chaperone BIP from the endoplasmic reticulum is fine-tuned postranslationally through the thermodynamic and kinetic alterations in its conformational ensemble of functionally and structurally distinct physiological forms.
    1. Cancer Biology

    Daam2 driven degradation of VHL promotes gliomagenesis

    Wenyi Zhu et al.
    The glial developmental factor, Daam2, promotes glioma tumorigenesis by degrading the VHL tumor suppressor, illustrating how dysregulation of gliogenic factors can impact tumor suppressor activity and promote glioma tumorigenesis.
    1. Genomics and Evolutionary Biology
    2. Neuroscience

    Co-expression of xenopsin and rhabdomeric opsin in photoreceptors bearing microvilli and cilia

    Oliver Vöcking et al.
    The recently characterized opsin group of xenopsins is likely a major player in animal eye evolution and may have been present in an ancient, highly plastic eye photoreceptor cell type.
    1. Computational and Systems Biology

    Systematic integration of biomedical knowledge prioritizes drugs for repurposing

    Daniel Scott Himmelstein et al.
    Project Rephetio combines data integration and systematic analysis to enable drug repurposing predictions on an unprecedented scale.

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