153 results found
    1. Developmental Biology

    Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network

    Shreyasi Mukherjee et al.
    Genomic analysis of Xenopus gastrula reveal that the transcription factor Sox17 interacts with the Wnt signaling effector ß-catenin on enhancers to regulate the transcriptional program underlying endoderm germ layer formation.
    1. Cell Biology

    A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1

    Natalia Felipe-Medina et al.
    Genetic and biochemical analysis reveal a variant in HSF2BP causing POI and C19ORF57/BRME1 as an interactor and stabilizer of HSF2BP by forming a complex with BRCA2, RAD51, RPA and PALB2.
    1. Cell Biology

    Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells

    Jaroslaw Cendrowski et al.
    Erythroid-enriched BMP2K kinase, in addition to its predicted function in endocytosis, regulates distribution and abundance of COPII assemblies and autophagic degradation through opposing actions of its two splicing variants.
    1. Developmental Biology
    2. Genetics and Genomics

    Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly

    Mingi Hong et al.
    A combination of window-of-sensitivity, genetic, and in vitro findings illuminate mechanisms of gene–environment interaction in a multifactorial model of a common birth defect.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Nongenetic inheritance and multigenerational plasticity in the nematode C. elegans

    L Ryan Baugh, Troy Day
    Evidence is mounting that environmentally-induced adaptive changes in phenotype can be transmitted across generations, but mechanistic gaps and theoretical concerns must be addressed to impact mainstream views of evolutionary adaptation.
    1. Medicine
    2. Neuroscience

    Deciphering the neural signature of human cardiovascular regulation

    Jorge Manuel et al.
    At least three hypothalamic subsystems are involved in cardiovascular regulation in humans.
    1. Biochemistry and Chemical Biology

    Controlling protein function by fine-tuning conformational flexibility

    Sonja Schmid, Thorsten Hugel
    Specific and non-specific conformational confinement, via point mutation or cochaperone interaction or macro-molecular crowding, stimulates protein function in Hsp90 by reducing non-productive conformational flexibility.
    1. Immunology and Inflammation

    CARD14E138A signalling in keratinocytes induces TNF-dependent skin and systemic inflammation

    Joan Manils et al.
    Expression of a psoriasis-associated CARD14E138A mutant in keratinocytes induces TNF-dependent localised skin and systemic inflammation independently of the adaptive immune system.
    1. Developmental Biology

    The Wg and Dpp morphogens regulate gene expression by modulating the frequency of transcriptional bursts

    Rachael Bakker et al.
    Experimental results in Drosophila support a model in which gene expression is fundamentally controlled by morphogens tuning the same transcription parameter for genes that are expressed in highly diverse patterns.
    1. Cell Biology
    2. Neuroscience

    Specific labeling of synaptic schwann cells reveals unique cellular and molecular features

    Ryan Castro et al.
    The discovery of markers specific to perisynaptic Schwann cells will accelerate the discovery of mechanisms important for their differentiation and function.

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