134 results found
    1. Developmental Biology

    Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis

    Stefan Donat et al.
    The cerebral cavernous malformations complex is controlled in a blood-flow sensitive manner and affects cardiac valve leaflet morphogenesis by regulating the expression of Klf2 and of Notch signalling activity.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Insight into the evolution of microbial metabolism from the deep-branching bacterium, Thermovibrio ammonificans

    Donato Giovannelli et al.
    The genome of Thermovibrio ammonificans encodes ancestral pathways (e.g., hydrogen oxidation) and more recently acquired ones (e.g., nitrate reduction) and a hybrid pathway for CO2 fixation.
    1. Neuroscience

    Long-term consequences of the absence of leptin signaling in early life

    Angela M Ramos-Lobo et al.
    A mouse model that grew without functional leptin receptors until adulthood reveals that early defects in leptin signaling lead to permanent metabolic and developmental problems.
    1. Evolutionary Biology

    Multifactorial processes underlie parallel opsin loss in neotropical bats

    Alexa Sadier et al.
    Parallel losses of short-wave light sensitivity in diverse bats occurred through independent changes at multiple steps in the conversion of genotype into functional phenotype, including pre-, during, and post-transcription.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication

    Jeziel Dener Damasceno et al.
    Duplication of Leishmania chromosomes combines S-phase DNA replication initiated at a single internal region with subtelomeric DNA replication detectable outside S-phase, potentially explaining genome plasticity in this important parasite.
    1. Evolutionary Biology

    The origin of the odorant receptor gene family in insects

    Philipp Brand et al.
    The insect odorant receptor gene family evolved at the base of the class Insecta before the evolution of flight and perhaps as an adaptation to terrestriality, and was therefore an important evolutionary novelty for insects.
    1. Neuroscience

    The causal role of the somatosensory cortex in prosocial behaviour

    Selene Gallo et al.
    A combination of human imaging and brain stimulation techniques show that the somatosensory cortex is essential to prosocial decision making, by transforming observed pain in accurate perception of others' distress.
    1. Structural Biology and Molecular Biophysics

    A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins

    Danish Khan et al.
    A new class of fungal hemoproteins is described that emphasizes the versatility of the Sec14-fold for translating binding of chemically distinct ligands to control of diverse sets of cellular activities.
    1. Genetics and Genomics
    2. Medicine

    Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study

    Chiara Fallerini et al.
    In the context of susceptibility to severe COVID-19, the observations of a study provide the basis for a personalized interferon-based therapy in patients with rare TLR7 variants.
    1. Neuroscience

    Pre-saccadic remapping relies on dynamics of spatial attention

    Martin Szinte et al.
    To see the world stable across saccades, the brain compensates retinal shifts induced by the movements, pre-saccadic maps of sensitivity reveal that this process takes time and follows attentional dynamics.

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