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    1. Immunology and Inflammation

    A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model

    Yasunobu Arima et al.
    Pain sensation induces relapse in a mouse model of multiple sclerosis via a sensory-sympathetic signaling pathway.
    1. Neuroscience

    Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors

    Prerana Shrestha et al.
    The well-established link between stress and depression could be due to the activity of a population of cells in prefrontal cortex that express a gene mutated in the rare disorder Wolfram syndrome.
    1. Neuroscience

    Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss

    Fredrick E Henry et al.
    Cell type-specific transcriptomics in energy homeostasis neurons has identified hundreds of genes and multiple signaling pathways that are regulated by weight loss in mice, as well as several previously unexamined genes that can regulate appetite and body weight.
    1. Developmental Biology
    2. Neuroscience

    Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets

    Youngshik Choe et al.
    During development the Sonic Hedgehog protein is produced by epithelial structures and acts at a distance in the brain and perhaps in other organs.
    1. Stem Cells and Regenerative Medicine

    Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells

    Nathan Kumar et al.
    An expandable cell population derived from human pluripotent stem cells exhibits properties of mesoderm and is restricted to differentiate into derivatives of intermediate mesoderm.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Cell-cycle quiescence maintains Caenorhabditis elegans germline stem cells independent of GLP-1/Notch

    Hannah S Seidel, Judith Kimble
    C. elegans germline stem cells become quiescent under starved conditions, and this quiescence maintains the stem cell state even in the absence of GLP-1/Notch signaling, which is otherwise essential for stem cell maintenance.
    1. Developmental Biology

    The REST remodeling complex protects genomic integrity during embryonic neurogenesis

    Tamilla Nechiporuk et al.
    The untimely loss of the transcriptional repressor REST from dividing neural progenitors during embryogenesis leads to compromised genomic integrity.
    1. Neuroscience

    A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin β1 subunit, Lamb1

    Yi Bessie Liu et al.
    A mouse with a defined mutation in an extracellular matrix protein that is expressed in selected neurons sheds light on circuit abnormalities producing transient hyperkinetic movements.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration

    Aida Rodrigo Albors et al.
    During axolotl spinal cord regeneration adult neural stem cells reactivate an embryonic neuroepithelial cell-like gene program that implements planar cell polarity to orient cell divisions, coupling polarized spinal cord growth with stem cell self-renewal.
    1. Neuroscience

    NG2 glia are required for vessel network formation during embryonic development

    Shilpi Minocha et al.
    The appearance of NG2+ glial cells in the dorsal telencephalon of the embryo coincides with the establishment of the brain blood vessel network in mice.