Browse the search results

Page 2 of 16
    1. Neuroscience
    2. Medicine

    Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women

    Stavros Trakoshis et al.
    Excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic males versus females.
    1. Neuroscience

    Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability

    Yuliya Voskobiynyk et al.
    BIN1 forms a complex with Tau and voltage-gated calcium channels in neurons, and higher BIN1 levels promote neuronal activity, calcium influx, and bursting that is blocked by reducing Tau.
    1. Immunology and Inflammation
    2. Neuroscience

    A new genetic strategy for targeting microglia in development and disease

    Gabriel L McKinsey et al.
    P2ry12-CreER robustly and specifically labels microglia in fate-mapping and ribosomal profiling experiments, revealing new markers for myeloid subpopulations in the central nervous system.
    1. Developmental Biology
    2. Neuroscience

    Clustered gamma-protocadherins regulate cortical interneuron programmed cell death

    Walter R Mancia Leon et al.
    Pcdhg determine survival of the GABAergic cortical interneuron population that is necessary to establish and maintain proper excitatory to inhibitory balance in the cerebral cortex.
    1. Neuroscience

    Phylogenetic variation in cortical layer II immature neuron reservoir of mammals

    Chiara La Rosa et al.
    The higher amount of cortical immature neurons in brains with expanded neocortices may represent a reservoir of young cells for mammals with reduced neurogenesis.
    1. Immunology and Inflammation
    2. Neuroscience

    Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain

    Jeremy Carlos Burns et al.
    Two novel subsets of microglia identified by their unique autofluorescence profiles differ in their subcellular organization, proteomic signatures and in their response to aging and lysosomal dysfunction.
    1. Stem Cells and Regenerative Medicine

    Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model

    Hyunah Lee et al.
    Sequential introduction of transcription factors enables large-scale generation of induced motor neurons (iMNs) from human somatic cells, and transplantation of iMNs exhibit therapeutic effects in spinal cord injury model.
    1. Cell Biology
    2. Immunology and Inflammation

    Formin-like 1 mediates effector T cell trafficking to inflammatory sites to enable T cell-mediated autoimmunity

    Scott B Thompson et al.
    Lymphocyte migration and autoimmunity induction rely on Formin-like 1-mediated actin network remodeling to push the lymphocyte nucleus through restrictive endothelial barriers.
    1. Neuroscience

    Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

    Magali Macchi et al.
    Heparan sulfate synthesis by mature oligodendrocytes creates a protective and permissive environment controling microglia and oligodendrocyte progenitors reactivation during remyelination.
    1. Neuroscience

    Remyelination alters the pattern of myelin in the cerebral cortex

    Jennifer Orthmann-Murphy et al.
    Regeneration of oligodendrocytes in the cerebral cortex results in reorganization of the pattern of myelination, potentially impacting information processing within cortical networks in diseases such as multiple sclerosis.