73 results found
    1. Biochemistry and Chemical Biology

    Inter-membrane association of the Sec and BAM translocons for bacterial outer-membrane biogenesis

    Sara Alvira et al.
    The protein translocation apparatus of the inner- (Sec) and outer-membrane (BAM) interact to form a trans-periplasmic super-complex capable of long-range, PMF-dependent conformational changes to facilitate efficient outer-membrane protein maturation.
    1. Physics of Living Systems

    Deciphering the regulatory genome of Escherichia coli, one hundred promoters at a time

    William T Ireland et al.
    A combination of massively parallel reporter assays and mass spectrometry uncovers the regulation of previously unexplored promoters across the Escherichia coli genome.
    1. Microbiology and Infectious Disease

    Defining the function of OmpA in the Rcs stress response

    Kilian Dekoninck et al.
    In vivo and in vitro approaches uncover a new function for the β-barrel OmpA and reveal how it interacts with the stress sensor lipoprotein RcsF.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Serine phosphorylation regulates the P-type potassium pump KdpFABC

    Marie E Sweet et al.
    Phosphorylation of a highly conserved serine residue is a physiological response of Escerichia coli to environmental potassium levels that inhibits transport by KdpFABC to maintain cellular homeostasis.
    1. Microbiology and Infectious Disease

    The Mla pathway in Acinetobacter baumannii has no demonstrable role in anterograde lipid transport

    Matthew J Powers et al.
    An outer membrane vesicle pulse-chase assay demonstrates that the Acinetobacter baumannii Mla system is a retrograde lipid transporter.
    1. Chromosomes and Gene Expression

    CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold

    Tom D Deegan et al.
    Ubiquitylation of the CMG helicase is inhibited throughout the initiation and elongation phases of chromosome replication by the DNA structure of a replication fork.
    1. Developmental Biology
    2. Neuroscience

    The role of the NMD factor UPF3B in olfactory sensory neurons

    Kun Tan et al.
    The nonsense-mediated RNA decay (NMD) branch-specific factor UPF3B influences olfactory sensory neuron cell populations, the olfactory receptor repertoire, and antimicrobial gene expression.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Gene autoregulation by 3’ UTR-derived bacterial small RNAs

    Mona Hoyos et al.
    Bacterial small RNAs derived from the 3' untranslated region of an mRNA can serve as autoregulatory elements.
    1. Structural Biology and Molecular Biophysics

    Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation

    Ljuvica R Kolich et al.
    Structure of MlaFB reveals how a small binding protein and the C-terminal tail on an ATPase subunit work together to regulate the assembly and function of an ABC transporter.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Identifying the immune interactions underlying HLA class I disease associations

    Bisrat J Debebe et al.
    HLA class I-disease associations have been studied for decades; a new approach for investigating the underlying mechanism can overcome past problems with interpretation and help to understand the etiology of human diseases.

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