Nikolai Hentze, Laura Le Breton ... Matthias P Mayer
Heat-induced local unfolding allows Hsf1 to form trimers and bind to DNA, which depends on Hsf1 concentration and is promoted, not inhibited, by Hsp90.
Yenisleidy Lorenzo-Ceballos, Willy Carrasquel-Ursulaez ... Ramon Latorre
Gating currents analysis at different Ca2+ concentrations of BK channels reveals a strong allosteric coupling between Ca2+- and voltage-sensing modules via equivalent contributions exerted by the RCK1 and RCK2 Ca2+-sites.
Making a link between deletion of transcription cis-regulatory elements by CrispR/Cas9, obtention of mutants with single muscle morphology defects and their impact on locomotion.
Neuronal serotonin release tunes transcription response times of Caenorhabditis elegans germ cells to promote the survival and stress resistance of future offspring.
André Kuhn, Sigurd Ramans Harborough ... Lars Østergaard
Auxin binding to the ETTIN transcription factor disrupts the interaction between ETT and a TPL/TPR co-repressor and subsequently affects chromatin dynamics to ensure proper gynoecium development.
Xiaobo Wang, Mary Ellenbecker ... Ekaterina Voronina
Complementary effects of FBF-1 and FBF-2 on germline stem cell dynamics result from their distinct cooperation with mRNA deadenylase resulting in the opposite effects on the shared target mRNAs.
The cortical collapse factor Efa6 limits axon growth and branching and maintains axonal microtubule bundle integrity by inhibiting microtubule polymerisation at the cell cortex.