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    1. Cell Biology
    2. Microbiology and Infectious Disease

    A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking

    Thomas Pohlmann et al.
    An endosomal component employs a novel PAM2-like motif to recruit a key RNA-binding protein, which explains how mRNAs and associated ribosomes are attached to endosomes during coupled transport.
    1. Genetics and Genomics

    Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation

    Bianca Hartmann et al.
    Mutations affecting a nuclear encoded metalloprotease cause of a new form of mitochondriopathy, highlighting the importance of this protease for mitochondrial function in humans.
    1. Cell Biology
    2. Developmental Biology

    Mitochondrial fusion is required for spermatogonial differentiation and meiosis

    Grigor Varuzhanyan et al.
    Mitochondrial fusion enables a metabolic transition during spermatogenesis.
    1. Stem Cells and Regenerative Medicine

    Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing

    Fu Yang et al.
    A Drosophila fertility gene is identified that acts as a linker between HP1a and local H3K4 demethylation during HP1a-mediated gene silencing that is required for ovary development and transposon silencing..
    1. Cell Biology
    2. Plant Biology

    Arabidopsis heterotrimeric G proteins regulate immunity by directly coupling to the FLS2 receptor

    Xiangxiu Liang et al.
    Heterotrimeric G proteins are coupled to and regulate plant receptor signaling, which allows optimum immune activation and enhances the production of reactive oxygen species.
    1. Developmental Biology
    2. Cancer Biology

    The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma

    Nathan M Krah et al.
    By regulating acinar cell differentiation, the transcription factor PTF1A acts as a novel class of tumor suppressor in pancreatic cancer.
    1. Cell Biology
    2. Neuroscience

    Dendritic mitochondria reach stable positions during circuit development

    Michelle C Faits et al.
    Mitochondria reach stable positions in dendrites during a critical developmental period of high motility.
    1. Developmental Biology
    2. Evolutionary Biology

    Embryo polarity in moth flies and mosquitoes relies on distinct old genes with localized transcript isoforms

    Yoseop Yoon et al.
    Isoform-specific transcript localization underlies the evolutionary diversity of anterior axis determinants in embryos of dipteran insects.
    1. Neuroscience

    Stomach-brain synchrony reveals a novel, delayed-connectivity resting-state network in humans

    Ignacio Rebollo et al.
    Coupling between the gastric rhythm and brain activity at rest reveals a novel resting-state network, characterized by delayed functional connectivity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    An ER translocon for multi-pass membrane protein biogenesis

    Philip T McGilvray et al.
    A set of ER-localized membrane proteins whose loss causes developmental diseases in humans, assemble with Sec61 into a translocon that facilitates the biogenesis of hundreds of different multi-pass membrane proteins.