4,184 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Myosin with hypertrophic cardiac mutation R712L has a decreased working stroke which is rescued by omecamtiv mecarbil

    Aaron Snoberger et al.
    Mechanochemical defects of a β-cardiac myosin mutation that results in severe hypertrophic cardiomyopathy are reported and the heart failure drug omecamtiv mecarbil rescues these defects.
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology

    Cell-accurate optical mapping across the entire developing heart

    Michael Weber et al.
    The combination of high-speed light sheet microscopy and suitable data analysis facilitates cell-accurate measurements across entire organs and opens the way to systematic, scale-bridging, in vivo studies of organogenesis.
    1. Neuroscience

    Mapping cortical mesoscopic networks of single spiking cortical or sub-cortical neurons

    Dongsheng Xiao et al.
    Mesoscale cortical calcium activity correlating with single cortical and thalamic cell spiking reveal rich dynamics and support a novel approach for investigating in vivo functional networks in the mammalian brain.
    1. Neuroscience

    A circuit mechanism for decision-making biases and NMDA receptor hypofunction

    Sean Edward Cavanagh et al.
    Ketamine, an NMDA receptor antagonist and experimental model for schizophrenia, produces decision-making deficits in monkeys, which are predicted by a lowering of cortical excitation-inhibition balance in a spiking circuit model.
    1. Computational and Systems Biology
    2. Ecology

    Tree crickets optimize the acoustics of baffles to exaggerate their mate-attraction signal

    Natasha Mhatre et al.
    Tree crickets can optimize the baffles they make to increase call loudness without any progressive optimization, and manufacture an optimal baffle in a single attempt, by using a simple yet highly accurate heuristic.
    1. Neuroscience

    Normative evidence accumulation in unpredictable environments

    Christopher M Glaze et al.
    Theoretically optimal dynamics for making decisions in unpredictable environments provide a broadly applicable framework for understanding choice behavior and underlying neural signals.
    1. Ecology
    2. Evolutionary Biology

    Quorums enable optimal pooling of independent judgements in biological systems

    James AR Marshall et al.
    Consideration of signal detection theory shows how decision ecology relates to optimal collective decisions, helping explain the prevalence of quorum-sensing in even the simplest collective systems, such as bacterial communities.
    1. Neuroscience
    2. Medicine

    Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women

    Stavros Trakoshis et al.
    Excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic males versus females.
    1. Neuroscience

    Optimal multisensory decision-making in a reaction-time task

    Jan Drugowitsch et al.
    Through a combination of modeling and experiments it is shown that humans can near-optimally accumulate decision-related evidence across time and cues even when reaction time is under their control.
    1. Neuroscience

    Receptor-driven, multimodal mapping of cortical areas in the macaque monkey intraparietal sulcus

    Meiqi Niu et al.
    The macaque monkey intraparietal sulcus encompasses 17 cyto- and receptorarchitectonically distinct areas, which can be grouped into three clusters based on (dis)similarities of their molecular structure.

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