Mechanochemical defects of a β-cardiac myosin mutation that results in severe hypertrophic cardiomyopathy are reported and the heart failure drug omecamtiv mecarbil rescues these defects.
The combination of high-speed light sheet microscopy and suitable data analysis facilitates cell-accurate measurements across entire organs and opens the way to systematic, scale-bridging, in vivo studies of organogenesis.
Mesoscale cortical calcium activity correlating with single cortical and thalamic cell spiking reveal rich dynamics and support a novel approach for investigating in vivo functional networks in the mammalian brain.
Ketamine, an NMDA receptor antagonist and experimental model for schizophrenia, produces decision-making deficits in monkeys, which are predicted by a lowering of cortical excitation-inhibition balance in a spiking circuit model.
Tree crickets can optimize the baffles they make to increase call loudness without any progressive optimization, and manufacture an optimal baffle in a single attempt, by using a simple yet highly accurate heuristic.
Theoretically optimal dynamics for making decisions in unpredictable environments provide a broadly applicable framework for understanding choice behavior and underlying neural signals.
Consideration of signal detection theory shows how decision ecology relates to optimal collective decisions, helping explain the prevalence of quorum-sensing in even the simplest collective systems, such as bacterial communities.
Through a combination of modeling and experiments it is shown that humans can near-optimally accumulate decision-related evidence across time and cues even when reaction time is under their control.
The macaque monkey intraparietal sulcus encompasses 17 cyto- and receptorarchitectonically distinct areas, which can be grouped into three clusters based on (dis)similarities of their molecular structure.
