685 results found
    1. Cell Biology

    Cross-compartment signal propagation in the mitotic exit network

    Xiaoxue Zhou et al.
    The mitotic exit network signals from spindle pole bodies to the nucleolus through the dynamic localization of its terminal kinase complex Dbf2-Mob1.
    1. Neuroscience

    Layer 6 ensembles can selectively regulate the behavioral impact and layer-specific representation of sensory deviants

    Jakob Voigts et al.
    Changing which layer 6 neurons are active during sensory tasks disrupts the detection and encoding of changes, but still allows integration of sensory information in the absence of changes.
    1. Neuroscience

    Human complex exploration strategies are enriched by noradrenaline-modulated heuristics

    Magda Dubois et al.
    Humans supplement complex, resource-demanding strategies with simple heuristics for solving the exploration-exploitation dilemma, and noradrenaline functioning controls their utilisation.
    1. Neuroscience

    Amplitude modulations of cortical sensory responses in pulsatile evidence accumulation

    Sue Ann Koay et al.
    From as early as primary visual cortex and across posterior cortical areas, neural responses to visual pulses during an evidence-accumulation task exhibit a multitude of task-related amplitude modulations/gain changes.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon

    Salah A Baker et al.
    An optogenetic dual-color Ca2+-imaging approach shows how submucosal pacemaker-cells, interstitial cells of Cajal, modulate smooth-muscle responses and drive colonic motility via complex Ca2+ signaling.
    1. Genetics and Genomics
    2. Neuroscience

    Fruitless mutant male mosquitoes gain attraction to human odor

    Nipun S Basrur et al.
    Engineering male mosquitoes lacking the fruitless gene induces them to be attracted to humans.
    1. Neuroscience

    Hippocampal low-frequency stimulation prevents seizure generation in a mouse model of mesial temporal lobe epilepsy

    Enya Paschen et al.
    Optogenetic and electrical low-frequency stimulation in the sclerotic hippocampus prevents the emergence of spontaneous focal and evoked generalized seizures in a mouse epilepsy model.
    1. Neuroscience

    A rapid whisker-based decision underlying skilled locomotion in mice

    Richard A Warren et al.
    A rapid whisker-based decision underlies skilled locomotion in mice largely independent of cerebral cortex.
    1. Neuroscience

    Circuit and synaptic organization of forebrain-to-midbrain pathways that promote and suppress vocalization

    Valerie Michael et al.
    Inhibitory neurons in the hypothalamus and amygdala push and pull on the midbrain vocal gating circuit to trigger and suppress ultrasonic vocalization (USV) production in the mouse.

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