213 results found
    1. Neuroscience

    ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain

    Jormay Lim et al.
    Mouse brain neurons response to transcranial ultrasound at the energy level of 5 mW/cm2 and repeated stimulations lead to neurogenesis while ASIC1a is required both in vitro and in vivo as one of the mechanoreceptors.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    3′HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression

    Pamela Himadewi et al.
    The 3'HS1 CTCF binding site directly modulates chromosomal loops to regulate γ-globin expression through the accession of the hereditary persistence of fetal hemoglobin enhancer.
    1. Cancer Biology
    2. Cell Biology

    Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation

    Brian Spurlock et al.
    A mitochondria-based 'priming' of stemness happens by fine-tuned repression of the level or activity of the master regulator of mitochondrial fission, Drp1, which supports carcinogen-induced transformation in a keratinocyte model.
    1. Developmental Biology
    2. Neuroscience

    Activity-dependent modulation of synapse-regulating genes in astrocytes

    Isabella Farhy-Tselnicker et al.
    RNA sequencing and genetic mouse models reveal that transcriptional changes to astrocytes in the developing cortex are not intrinsic but influenced by their environment and determine that expression of astrocyte synapse-regulating genes and neuronal synaptogenesis is modulated by ongoing astrocyte-neuron communication.
    1. Cell Biology
    2. Neuroscience

    Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome

    Anitha P Govind et al.
    Neuronal activity triggers the dispersal of the Golgi into dendritic Golgi satellites, leading to reshaping of the neuronal surface glycoproteome through processing of glycans to mature, sialic acid-containing forms.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    A morphological transformation in respiratory syncytial virus leads to enhanced complement deposition

    Jessica P Kuppan et al.
    Respiratory syncytial virus produces filamentous particles that change shape when the viral matrix detaches from the viral membrane, and this change in shape results in enhanced deposition of complement proteins, with potential downstream consequences.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The interplay of RNA:DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions

    Charanya Kumar et al.
    Reconstitution of orientation-specific R-loop-replisome collisions with purified proteins reveals the differential impact of R-loop-associated RNA:DNA hybrids and G-quadruplexes on replication fork progression.
    1. Evolutionary Biology

    Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies

    Angela M Phillips et al.
    CR9114, one of the most broadly neutralizing anti-influenza antibodies characterized to date, acquires affinity to divergent HA subtypes sequentially, due to higher order interactions between the nested sets of mutations required for binding each distinct subtype.
    1. Neuroscience

    Heterogeneous side effects of cortical inactivation in behaving animals

    Ariana R Andrei et al.
    Focal optogenetic inactivation of cortex induces complex changes in neural responses outside the targeted area that can influence behavioral performance.
    1. Cell Biology
    2. Immunology and Inflammation

    Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration

    Janine JG Arts et al.
    Neutrophils use dorsal membrane protrusions of endothelial cells to cross the vascular wall.

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