Genome-wide measurements on mouse liver cells show that transcription, and a particular key transcription factor, have a smaller than expected influence on the mouse circadian system.

Sugar levels in leaves act as a signal for plants to switch from their juvenile to their adult form by regulating the expression of two genes.

A gene that codes for a transcription factor that is involved in lipid and carbohydrate metabolism also has a role in the regulation of circadian rhythms.

Chronic and excessive inflammation can lead to exhaustion of the supply of hematopoietic stem cells and to myeloid malignancies in mice, mimicking important aspects of the myelodysplastic syndrome found in humans.

The transport of proteins along flagellar microtubules generates the force that enables flagella to propel cells across surfaces.

In a mouse model of neurodegeneration, hippocampal firing sequences that normally encode spatial memories become disengaged from external space.

The basal body of the type-III secretion system of Yersinia enterocolitica within bacterial membranes shows elasticity and is longer than related isolated systems.

Quantification of all the major on- and off-pathway kinetic parameters in the transcription elongation cycle reveals that RNA polymerase II translocates slowly in a linear, non-branched Brownian ratchet mechanism.

A new electron diffraction technique called MicroED allows protein structures to be determined from three-dimensional microcrystals.

The therapeutic effects of the sleeping pill zolpidem in patients with disorders of consciousness may be due to recruitment of brain cells idling in abnormally low-frequency brain waves.