Integration of GWAS summary statistics with extensive 3D genomic datasets generated in a myriad of different cell types provides genomic insights into pediatric obesity pathogenesis.

The naturally occurring biologics, FLO and HC-HA/PTX3, derived from human birth tissues, may be developed as a much-needed non-opioid therapy for post-surgical pain treatment, leveraging robust neuronal mechanisms.

Despite no observed correlation between retrotransposon (RTE) activity and chronological age, the expression of most RTE classes and families except SINEs correlated with biological age-associated gene signature scores.

A multi-disciplined approach uncovered microRNA-199a/b-5p as important regulators of chondrogenesis, which negatively regulate mRNAs such as FZD6, ITGA3, and CAV1 for protective purposes during chondrogenesis.

Molecular and biochemical approaches in primary human cells illustrate how a nuclear RNA-binding protein is shifted to the surface of osteoclasts – setting their size and biological activity.

A novel in vivo role for miRNAs Mir221/222 in arthritogenic synovial fibroblasts and progression of arthritis is presented.

This time-shortened work flow improves sensitivity and specificity for the identification of bacteria in bone infections independently of bacterial culturability.