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    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Cell-type diversity and regionalized gene expression in the planarian intestine

    David J Forsthoefel, Nicholas I Cejda ... Phillip A Newmark
    Application of laser-capture microdissection to planarian intestinal tissue provides a new tool for analysis of tissue-specific gene expression in flatworms, and a new resource to advance investigations of gastrointestinal regeneration.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

    Qin Li, Sika Zheng ... Douglas L Black
    PTBP2 ensures that adult protein variants are expressed only in mature neurons through regulation of alternative splicing during early neuronal development.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A single cell transcriptional roadmap of human pacemaker cell differentiation

    Alexandra Wiesinger, Jiuru Li ... Harsha D Devalla
    Diversification of human pacemaker subpopulations is directed by WNT and TGFβ signaling.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Systematic bacterialization of yeast genes identifies a near-universally swappable pathway

    Aashiq H Kachroo, Jon M Laurent ... Edward M Marcotte
    Despite billions of years of divergence, a majority of prokaryotic genes can functionally replace their essential eukaryotic counterparts, revealing broad preservation of ancestral functions and identifying heme biosynthesis as a near-universally swappable pathway.
    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon, Sarah E Lower ... Jing-Ke Weng
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
    1. Evolutionary Biology
    2. Plant Biology

    Positive selection and relaxed purifying selection contribute to rapid evolution of male-biased genes in a dioecious flowering plant

    Lei Zhao, Wei Zhou ... Hong-Tao Li
    Computational analyses, for the first time in plants, reveal how male-biased genes evolve faster than female-biased and unbiased genes.
    1. Evolutionary Biology

    Mammalian forelimb evolution is driven by uneven proximal-to-distal morphological diversity

    Priscila S Rothier, Anne-Claire Fabre ... Anthony Herrel
    The diversification of hand bones in mammals was much more dynamic than those of the proximal and intermediate forearm, involving higher morphological diversity, stronger integration, and greater evolutionary lability at distal structures.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Cutting Edge: Building bridges between cellular and molecular structural biology

    Ardan Patwardhan, Robert Brandt ... Gerard J Kleywegt
    The integration of structural data from different imaging scales requires the development of standards and tools for representing the segmentation and transformation of data, and for the annotation of biological structures.
    1. Medicine

    Improvement of muscle strength in a mouse model for congenital myopathy treated with HDAC and DNA methyltransferase inhibitors

    Alexis Ruiz, Sofia Benucci ... Francesco Zorzato
    Physiological and biochemical studies show that the treatment of a transgenic mouse model carrying recessive Ryr1 mutations with a combination of class II histone deacetylase inhibitors and DNA methyl transferase inhibitors significantly improves skeletal muscle function.
    1. Computational and Systems Biology

    Science Forum: Wikidata as a knowledge graph for the life sciences

    Andra Waagmeester, Gregory Stupp ... Andrew I Su
    Wikidata is continuously-updated resource that could improve the efficiency and accuracy of research in many areas of the life and biomedical sciences.