Polycystic ovary syndrome (PCOS) is a highly prevalent disorder of women, with significant reproductive, endocrine, and metabolic morbidities and a total healthcare-related economic burden exceeding $15 billion (2021 USD) for the U.S. alone, $4 billion due to mental health disorders.

A survey of the transcriptomic landscape of the mouse ovary at the single-cell level reveals both the cellular complexity of this organs and the dynamic nature of the cellular states that accompany estrous cycling.

Single-cell transcriptomics of the zebrafish ovary identifies both major and minor cell types and provides a valuable resource for researchers interested in reproductive biology, stem cell biology, and aquatic toxicology.

A detailed characterization of mouse ovary development using tissue clearing and 3D lightsheet imaging identifies ovary folding, specification of cortical and medullary domains, and ovary encapsulation as major hallmarks of ovary morphogenesis.

Androgen receptor activation modifies B cell frequencies and functionality, accompanied by weight gain in female mice exposed to human PCOS IgG, highlighting the unrecognized involvement of B cells in PCOS autoimmune comorbidities despite their absence not preventing PCOS phenotype development.

Making human stem cells express certain transcription factors can convert them into cells that are similar to ovarian granulosa cells, and perform several important functions of the ovary.

Common mouse models of polycystic ovary syndrome (PCOS) have variable ability to recapitulate the increased GnRH pulse generator frequency thought to exist in women with PCOS.

Just 2-4 follicle stem cells maintain each follicle epithelium in the Drosophila ovary, and they reside within a single ring at the anterior edge of the tissue.

The fatty acid binding protein (FABP) family of proteins plays a role in multiple myeloma cell survival and disease progression in vitro and in silico, and thus blocking the FABPs could have anti-cancer effects and prove beneficial for myeloma patients.

A protein modification called O-linked glycosylation regulates the interactions between vimentin molecules under normal conditions, and the ability of Chlamydia bacteria to replicate after they infect cells.