147 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis

    Xiaodan Ji et al.
    Transcription elongation by the elongation factor P-TEFb promotes the epithelial–mesenchymal transition and metastasis of breast cancer cells, implicating inhibition of this factor as a potential treatment for the late stages of this cancer.
    1. Microbiology and Infectious Disease

    TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb

    Xiancai Ma et al.
    TRIM28 was found to be a versatile dual-function latency contributor by bridging both suppressive epigenetic modifications and RNAP II transcriptional-pausing, and can be a novel target to develop latency-reversing agents.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter

    Ursula Schulze-Gahmen et al.
    AFF4 increases the combined selectivity of HIV Tat and TAR for super elongation complexes 330-fold over P-TEFb alone.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat

    Ursula Schulze-Gahmen et al.
    Structure-function analysis of the super elongation complex formed when HIV replicates inside cells reveals that the HIV-1 Tat protein binds to a cleft between P-TEFb, an enzyme that is involved in normal transcription, and AFF4, a protein that is used to build the super elongation complex
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons

    Iris Jonkers et al.
    The elongation rate of RNA Polymerase II varies greatly between and along genes, as this enzyme accelerates from stable pausing to rapid elongation within genes, and is influenced by CG-content, exons and chromatin.
    1. Biochemistry and Chemical Biology

    The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation

    Tyler B Faust et al.
    The HIV-1 Tat protein hijacks host non-degradative ubiquitination to trigger the nuclear import of the transcription elongation factor, P-TEFb.
    1. Chromosomes and Gene Expression

    HIV: The two sides of Tat

    Matjaz Barboric, Koh Fujinaga
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    1. Cancer Biology

    Reproducibility in Cancer Biology: Small molecules remain on target for c-Myc

    Linchong Sun, Ping Gao
    Targeting the transcription factor c-Myc via one of its coactivator proteins is a promising strategy for cancer therapy.
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    1. Cell Biology

    Metformin extends C. elegans lifespan through lysosomal pathway

    Jie Chen et al.
    Metformin extends C. elegans lifespan through lysosome-dependent coordination of TORC1 and AMPK pathways.

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