459 results found
    1. Neuroscience

    Boosts in brain signal variability track liberal shifts in decision bias

    Niels A Kloosterman et al.
    Modulation of moment-to-moment irregularity of neural activity closely tracks our ability to flexibly adapt decision biases to the environment.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A single point mutation in the Plasmodium falciparum FtsH1 metalloprotease confers actinonin resistance

    Christopher D Goodman et al.
    Actinonin kills malaria parasites by targeting the apicoplast-associated metalloprotease FTSH1.
    1. Cancer Biology

    Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

    Zeyad D Nassar et al.
    DECR1, a rate-limiting enzyme for polyunsaturated fatty acid (PUFA) β-oxidation, is an androgen-repressed gene in prostate cancer cells that limits oxidative stress to promote cancer cell survival.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Emergence and diversification of a host-parasite RNA ecosystem through Darwinian evolution

    Taro Furubayashi et al.
    In an in vitro RNA replication system, an RNA spontaneously diversifies and continuously evolves through coevolution with parasitic entities.
    1. Structural Biology and Molecular Biophysics

    Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation

    Ljuvica R Kolich et al.
    Structure of MlaFB reveals how a small binding protein and the C-terminal tail on an ATPase subunit work together to regulate the assembly and function of an ABC transporter.
    1. Neuroscience

    Sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples

    Hong-Viet Ngo et al.
    Triggered by (long-duration) hippocampal ripples, spindles facilitate communication between the hipppocampus and neocortex during natural sleep.
    1. Developmental Biology
    2. Immunology and Inflammation

    Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung at single cell resolution

    Racquel Domingo-Gonzalez et al.
    Single cell transcriptomics reveal a complex orchestration of lung immune cells during the transition from fetal to air-breathing life to fill context-specific functions in tissue remodeling, angiogenesis, and immunity.
    1. Microbiology and Infectious Disease

    Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP

    Dennis Klug et al.
    Exchange of the I domain in the Plasmodium surface protein TRAP against evolutionary distant I domains rescues infectivity of sporozoites.
    1. Human Biology and Medicine
    2. Neuroscience

    Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm

    Heidi IL Jacobs et al.
    By combining ultra-high-field imaging with physiological and saliva measures it is established that interactions between locus coeruleus, hippocampus and amygdala vary along emotional memory stages, putatively reflecting distinct cognitive states.
    1. Biochemistry and Chemical Biology

    Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations

    Ryan R Cupo, James Shorter
    Skd3 (human ClpB) is a potent ATP-dependent mitochondrial protein disaggregase that is activated by the rhomboid protease, PARL, and inactivated by MGCA7-linked mutations.

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