Browse the search results

Page 2 of 53
    1. Evolutionary Biology

    Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation

    Grant Kinsler et al.
    A set of adaptive mutations affect only a small number of phenotypes that matter in the evolution condition, and yet contain substantial latent functional diversity revealed in distant environments.
    1. Cancer Biology

    Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

    László Bányai et al.
    In contrast with earlier conclusions, negative selection has a major role in cancer evolution.
    1. Structural Biology and Molecular Biophysics

    Structural basis for transcription complex disruption by the Mfd translocase

    Jin Young Kang et al.
    Seven distinct cryo-electron microscopy structures delineate the elaborate mechanism for how E. coli Mfd, a transcription repair coupling factor, disassembles the RNA polymerase transcription elongation complex to initiate transcription-coupled repair.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Diverse viral proteases activate the NLRP1 inflammasome

    Brian V Tsu et al.
    Proteases from diverse viruses, the first described pathogen-encoded activators of human NLRP1, cleave NLRP1 at a sequence that mimics the viral polyprotein, resulting in inflammasome activation and pro-inflammatory cytokine release.
    1. Computational and Systems Biology
    2. Medicine

    Reproducible analysis of disease space via principal components using the novel R package syndRomics

    Abel Torres-Espín et al.
    A tutorial and open-source software to aid in reproducible disease pattern detection using principal component analysis.
    1. Epidemiology and Global Health

    A modular approach to integrating multiple data sources into real-time clinical prediction for pediatric diarrhea

    Ben J Brintz et al.
    Using a modular approach to integrate multiple data sources for the prediction of diarrhea etiology has the potential to reduce inappropriate antibiotics prescription in low-resource settings.
    1. Biochemistry and Chemical Biology
    2. Medicine

    The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

    Omar Al Rifai et al.
    In mice, but not in humans, the bone-derived hormone osteocalcin is O-glycosylated, a post-translational modification controlling its half-life in vivo.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium

    Madeline Sandoval et al.
    Skin epithelium can tolerate oncogene-expressing clones through a novel cellular mechanism of inter-clonal competition between renewing progenitors along the clone's edge and differentiating progenitors within the clone's core.
    1. Cell Biology
    2. Computational and Systems Biology

    Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells

    Peter Jan Hooikaas et al.
    Kinesin-4 KIF21B promotes rapid reorientation of the microtubule network during formation of immunological synapse in T cells by acting as a pausing and catastrophe-inducing factor that keeps microtubules short.
    1. Developmental Biology
    2. Neuroscience

    Dentate gyrus development requires a cortical hem-derived astrocytic scaffold

    Alessia Caramello et al.
    An astrocytic scaffold that depends on SOX9 guides embryonic neuronal progenitors toward the developing dentate gyrus.