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Upregulation of TRPM3 in nociceptors innervating inflamed tissue
Marie Mulier et al.
The expression and function of the cation channel TRPM3 is strongly increased in sensory neurons innervating inflamed tissue, likely contributing to inflammatory hyperalgesia and persistent pain.
Antagonistic control of
germline stem cell proliferation and differentiation by PUF proteins FBF-1 and FBF-2
Xiaobo Wang et al.
Complementary effects of FBF-1 and FBF-2 on germline stem cell dynamics result from their distinct cooperation with mRNA deadenylase resulting in the opposite effects on the shared target mRNAs.
KATANIN-dependent mechanical properties of the stigmatic cell wall mediate the pollen tube path in Arabidopsis
Lucie Riglet et al.
KATANIN1 in stigma papilla cells prevents disordered pollen tube growth and straightens pollen tube direction, allowing the pollen tube to find its correct path to the underlying female tissues.
Genetics and Genomics
Population-scale proteome variation in human induced pluripotent stem cells
Bogdan Andrei Mirauta et al.
Protein abundance changes across human-induced pluripotent stem cell lines reflect genetic variation across donors, with underlying mechanisms including modulation of RNA expression and modification of protein-coding sequences.
Immunology and Inflammation
Estrogen exacerbates mammary involution through neutrophil-dependent and -independent mechanism
Chew Leng Lim et al.
Estrogen aggravates mammary involution through lysosome-mediated cell death, neutrophil recruitment via CXCR2 signalling, neutrophil-mediated inflammation and adipocyte repopulation.
Structural Biology and Molecular Biophysics
Molecular principles of assembly, activation, and inhibition in epithelial sodium channel
Sigrid Noreng et al.
The in-depth structural and functional work provide a deeper understanding as to how the epithelial sodium channel is a heteromeric ion channel that is regulated by Na
Boosts in brain signal variability track liberal shifts in decision bias
Niels A Kloosterman et al.
Modulation of moment-to-moment irregularity of neural activity closely tracks our ability to flexibly adapt decision biases to the environment.
Microbiology and Infectious Disease
A single point mutation in the
FtsH1 metalloprotease confers actinonin resistance
Christopher D Goodman et al.
Actinonin kills malaria parasites by targeting the apicoplast-associated metalloprotease FTSH1.
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis
Zeyad D Nassar et al.
DECR1, a rate-limiting enzyme for polyunsaturated fatty acid (PUFA) β-oxidation, is an androgen-repressed gene in prostate cancer cells that limits oxidative stress to promote cancer cell survival.
Biochemistry and Chemical Biology
Emergence and diversification of a host-parasite RNA ecosystem through Darwinian evolution
Taro Furubayashi et al.
In an in vitro RNA replication system, an RNA spontaneously diversifies and continuously evolves through coevolution with parasitic entities.
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