130 results found
    1. Neuroscience

    Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model

    Kevin P Koster et al.
    NMDA receptor function is regulated by protein depalmitoylation during visual cortical maturation and is dysfunctional in infantile neuronal ceroid lipofuscinosis.
    1. Microbiology and Infectious Disease

    Plasmodium P36 determines host cell receptor usage during sporozoite invasion

    Giulia Manzoni et al.
    Host CD81 and Scavenger Receptor BI operate independently to mediate invasion of hepatocytes by different species of Plasmodium sporozoites, which use the parasite protein P36 as a key determinant of the entry route.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Blood-stage immunity to Plasmodium chabaudi malaria following chemoprophylaxis and sporozoite immunization

    Wiebke Nahrendorf et al.
    A novel mouse model of immunization against Plasmodium chabaudi involving infectious mosquito bites and drug-treatment elicits protection against blood-stage malaria parasites, and shows that protection is not necessarily life cycle stage-specific.
    1. Microbiology and Infectious Disease

    Malaria: Cracking Ali Baba’s code

    Oliver Billker
    A protein called P36 holds the key to how different species of malaria parasite invade liver cells.
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    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells

    João D Dias et al.
    Lysine mono- and di-methylation are two novel post-translational modifications of RNA polymerase II, which are enriched at promoters of active genes, precede lysine acetylation and mark early stages of transcription.
    1. Developmental Biology

    ZP4 confers structural properties to the zona pellucida essential for embryo development

    Ismael Lamas-Toranzo et al.
    Zona pellucida requires ZP4 protein to efficiently protect the developing embryo during in vivo pre-implantation development.
    1. Chromosomes and Gene Expression

    PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells

    Shuchi Agrawal Singh et al.
    A key transcription-factor for osteogenic differentiation, PLZF, acts as a transcriptional activator by binding to active developmental enhancers and facilitates mediator recruitment, but is not involved in enhancer looping.
    1. Microbiology and Infectious Disease

    Shed EBA-175 mediates red blood cell clustering that enhances malaria parasite growth and enables immune evasion

    May M Paing et al.
    Plasmodium falciparum invasion protein EBA-175, once shed from the parasite surface post invasion, facilitates RBC clustering and enhances parasite growth while simultaneously enabling parasite immune evasion of host neutralizing antibodies.
    1. Chromosomes and Gene Expression

    The nucleosomal barrier to promoter escape by RNA polymerase II is overcome by the chromatin remodeler Chd1

    Peter J Skene et al.
    The ATP-dependent chromatin remodeler Chd1 controls nucleosome turnover to allow RNA Polymerase to transcribe in vivo.
    1. Developmental Biology

    A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells

    Qiuyu Guo et al.
    β-Catenin-mediated expansion of nephron progenitors is independent of direct β-catenin/chromatin engagement, while progenitor induction proceeds with a β-catenin-driven switch of repressive TCFL1/TCFL2 to activating TCF7/LEF1 factors on transcriptionally poised enhancers.

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