511 results found
    1. Cell Biology
    2. Immunology and Inflammation

    CD56 regulates human NK cell cytotoxicity through Pyk2

    Justin T Gunesch et al.
    CD56/NCAM, the prototypical marker of human natural killer cells, promotes lytic function towards susceptible target cells by signaling through protein tyrosine kinase 2 (Pyk2).
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Local frustration determines loop opening during the catalytic cycle of an oxidoreductase

    Lukas S Stelzl et al.
    The cysteine pair oxidation state in nDsbD acts as a ‘switch’ controlling the presence or absence of frustration in the active-site and determining the dynamic behavior of the cap loop.
    1. Human Biology and Medicine

    TMAO, a seafood-derived molecule, produces diuresis and reduces mortality in heart failure rats

    Marta Gawrys-Kopczynska et al.
    Trimethylamine-oxide (TMAO), a molecule present in seafood, reduces mortality and exerts beneficial effects on the circulatory system in heart failure rats.
    1. Computational and Systems Biology
    2. Developmental Biology

    The dynamic transmission of positional information in stau- mutants during Drosophila embryogenesis

    Zhe Yang et al.
    In stau-mutants, the Hunchback boundary shifts posteriorly by 10% EL but shows comparable variability to that of the wild type in short time windows in nuclear cycle 14.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Tgfβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration

    Deepak A Kaji et al.
    TGFß signaling regulates migration of tenogenic cells from Scx- and non-Scx lineages and is required for functional regeneration after neonatal tendon injury.
    1. Cell Biology
    2. Neuroscience

    Synaptotagmin-1 is the Ca2+ sensor for fast striatal dopamine release

    Aditi Banerjee et al.
    Genetic and electrophysiological analyses reveal calcium-triggering mechanisms for dopamine release in the striatum that may enable fast and slow dopamine coding.
    1. Biochemistry and Chemical Biology

    Diverse nucleosome Site-Selectivity among histone deacetylase complexes

    Zhipeng A Wang et al.
    By analyzing five purified recombinant histone deacetylase complexes and designer acetylated mononucleosome substrates, the molecular basis of the unusual substrate specificity of the CoREST complex was revealed.
    1. Neuroscience

    SynGAP isoforms differentially regulate synaptic plasticity and dendritic development

    Yoichi Araki et al.
    Detailed SYNGAP1 splice variant characterization uncovers distinct isoform functions and biochemical properties contributing to critical aspects of neurodevelopment, providing previously unknown isoform-level insight into SYNGAP1-related cognitive disorders.
    1. Stem Cells and Regenerative Medicine

    Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model

    Hyunah Lee et al.
    Sequential introduction of transcription factors enables large-scale generation of induced motor neurons (iMNs) from human somatic cells, and transplantation of iMNs exhibit therapeutic effects in spinal cord injury model.
    1. Microbiology and Infectious Disease

    A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission

    Aurélia C Balestra et al.
    Multiple steps of the atypical cell cycles underlying Plasmodium gametogony are controlled by a divergent cyclin/cyclin-dependent complex.

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