7,093 results found
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation

    Susan Martin, Jessica Tyrrell ... Hanieh Yaghootkar
    Using genetics, it is possible to uncouple higher adiposity from its adverse metabolic effects and show that some obesity-associated conditions may benefit from treating the metabolic effects alone, whilst others may benefit more from weight loss.
    1. Computational and Systems Biology

    The MR-Base platform supports systematic causal inference across the human phenome

    Gibran Hemani, Jie Zheng ... Philip C Haycock
    Compiling public datasets into a single, centralised repository and linking directly to analytical software completely transforms the scale and scope of causal inference across the phenome.
    1. Ecology
    2. Epidemiology and Global Health

    Using mobile phones as acoustic sensors for high-throughput mosquito surveillance

    Haripriya Mukundarajan, Felix Jan Hein Hol ... Manu Prakash
    Mobile phones can accurately capture sound recordings from mosquito wingbeats with species-specific frequencies, together with metadata about the recording time, location and conditions, to enable rapid low-cost mosquito surveillance using a citizen-science approach.
    1. Genetics and Genomics
    2. Neuroscience

    Neural mechanisms of parasite-induced summiting behavior in ‘zombie’ Drosophila

    Carolyn Elya, Danylo Lavrentovich ... Benjamin de Bivort
    In zombie fruit flies, Entomophthora muscae-elicited summiting behavior is mediated by blood-borne factors and the host circadian-neurosecretory network.
    1. Cell Biology
    2. Developmental Biology

    Casein kinase 1 family proteins promote Slimb-dependent Expanded degradation

    Alexander D Fulford, Maxine V Holder ... Paulo S Ribeiro
    The tissue growth controlling Hippo signalling pathway is modulated by the activity of the Casein Kinase 1 family, which regulates the protein stability of the upstream Hippo pathway component Expanded.
    1. Cancer Biology

    Dual targeting of histone deacetylases and MYC as potential treatment strategy for H3-K27M pediatric gliomas

    Danielle Algranati, Roni Oren ... Efrat Shema
    Combined inhibition of oncogenic and epigenetic pathways results in a substantial decrease in the viability and growth of H3-K27M pediatric glioma models.
    1. Evolutionary Biology
    2. Neuroscience

    The evolution and biological correlates of hand preferences in anthropoid primates

    Kai R Caspar, Fabian Pallasdies ... Sabine Begall
    Primate hand preference strength but not direction (left vs. right) generally reflects phylogeny and ecology at species level, but human handedness deviates markedly from all other species.
    1. Developmental Biology
    2. Genetics and Genomics

    MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

    Meltem Weger, Benjamin D Weger ... Thomas Dickmeis
    The glucose-sensing transcription factor MondoA regulates zebrafish epiboly via cholesterol biosynthesis genes including the human disease gene Nsdhl, revealing an unknown role for metabolic glucose signalling in vertebrate development.
    1. Evolutionary Biology

    Giant extinct caiman breaks constraint on the axial skeleton of extant crocodylians

    Torsten M Scheyer, John R Hutchinson ... Marcelo R Sánchez-Villagra
    The giant caiman Purussaurus from the Miocene of Venezuela is the first recorded member of crown Crocodylia having three sacrals, thus breaking the otherwise strict vertebral constraint of the group.
    1. Genetics and Genomics

    A new genus of horse from Pleistocene North America

    Peter D Heintzman, Grant D Zazula ... Beth Shapiro
    The extinct stilt-legged equids of North America are not related to Asiatic asses or horses, but instead represent a distinct lineage outside of living equid diversity that became extinct in the terminal Pleistocene.

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