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Genome editing in a close unicellular relative of animals suggests a premetazoan function of the Hippo pathway effector YAP/TAZ/Yorkie in the regulation of cytoskeletal dynamics and multicellular morphogenesis but not proliferation.

Genetic analysis of Hippo pathway kinases in a close unicellular relative of animals suggests an ancestral role of this ancient pathway in regulating cytoskeletal dynamics and density of multicellular aggregates.

MgADP binding to the high-affinity 'consensus' ATPase active site of SUR1 and remodeling of the L0-loop (lasso region) overrides tonic ATP inhibition of KATP channels.

Oligodendrocyte-lineage cells secrete L-type prostaglandin synthase in an autocrine loop to promote oligodendrocyte development and myelination.

The control of local cell properties such as epithelial cell number and mechanical force production by Hippo signaling is a major determinant of lung branching.

Assessments using chemogenetic and pharmacological approaches reveal that modulation of the activities of oxytocin neurons in the hypothalamus of the central nervous system could inhibit colorectal cancer progression in mice.

The yeast APC/C cryo-EM structure reveals substantial similarities with the human APC/C structure but also important differences in mechanisms of phosphorylation-dependent regulation and activation by coactivators.

Multiple non-redundant features of non-rapid eye movement sleep are altered in schizophrenia and largely independent of waking electrophysiological abnormalities, supporting the promise of neuropsychiatric disease biomarkers based on a precise dissection of the sleep.

The tumor suppressor APC regulates a metabolic program that drives normal intestinal differentiation in zebrafish.

The anaphase promoting complex (APC) has an essential role in ubiquitin-mediated proteolysis in the disassembly of cilia.