9,209 results found
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular determinants of large cargo transport into the nucleus

    Giulia Paci et al.
    Efficient nuclear transport of very large biomolecules, relevant for viral transport, scales non-linearly with size and its kinetics can be explained by a simple two-parameter energetic model.
    1. Neuroscience

    Extracellular space preservation aids the connectomic analysis of neural circuits

    Marta Pallotto et al.
    Automated segmentation of neurons and identification of synapses in electron micrographs is significantly improved by using simple modifications to chemical fixation protocols that preserve extracellular space in the brain.
    1. Neuroscience

    Extracting grid cell characteristics from place cell inputs using non-negative principal component analysis

    Yedidyah Dordek et al.
    Computational modeling of the brain’s navigation system reveals that place cells can drive the formation of hexagonal patterns experimentally observed in grid cells activity.
    1. Neuroscience

    Rapid categorization of natural face images in the infant right hemisphere

    Adélaïde de Heering, Bruno Rossion
    Diverse photographs of human faces against their natural background trigger a specific electrical response in the right hemisphere of the brain in infants aged 4–6 months.
    1. Neuroscience

    Theta-modulation drives the emergence of connectivity patterns underlying replay in a network model of place cells

    Panagiota Theodoni et al.
    The learning rate for novel spatial environments in model networks of place cells is determined by the product of the window for plasticity and the auto-correlation of place-cell activity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

    Ioanna Oikonomidi et al.
    Secretion of the inflammatory cytokine TNF requires a protein called iTAP/FrmD8, which controls the cell surface stability of the TNF shedding machinery, iRhom2 and TACE/ADAM17.
    1. Neuroscience

    Hippocampal place cells construct reward related sequences through unexplored space

    H Freyja Ólafsdóttir et al.
    In anticipation of a reward, hippocampal place cells simulate desired journeys through areas that have been seen, but not explored.
    1. Neuroscience

    Place cells on a maze encode routes rather than destinations

    Roddy M Grieves et al.
    Place cells in the rat hippocampus encode positions along well-learned routes as opposed to intended destinations.
    1. Ecology
    2. Neuroscience

    Individual recognition and the ‘face inversion effect’ in medaka fish (Oryzias latipes)

    Mu-Yun Wang, Hideaki Takeuchi
    Medaka fish were able to use faces for individual recognition, and were slower to recognise inverted faces but not inverted non-face shapes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

    Adam Graham Grieve et al.
    The iRhom2 protein, a catalytically inactive relative of rhomboid proteases, controls inflammation and growth factor signalling by acting as an essential multifunctional regulatory subunit of the cell surface shedding protease TACE (ADAM17).

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