38 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation

    Martijn S Luijsterburg et al.
    A new mechanism is uncovered by which the RNF168 ubiquitin ligase couples PALB2-dependent homologous recombination to H2A ubiquitylation to promote DNA repair and preserve genome integrity.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells

    Jaigeeth Deveryshetty et al.
    Biochemical studies revealed novel property of human tumor suppressor PALB2, which significantly contribute into DNA repair in cells and can be targeted for the development of novel anticancer treatment.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance

    Rachel W Anantha et al.
    Systematic analyses of natural variants and artificial mutants establish functional landscapes of BRCA1 for homology-directed repair (HDR) and therapy resistance and identify the BRCA1-PALB2 interaction as a key control point for HDR pathway choice.
    1. Cell Biology

    A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1

    Natalia Felipe-Medina et al.
    Genetic and biochemical analysis reveal a variant in HSF2BP causing POI and C19ORF57/BRME1 as an interactor and stabilizer of HSF2BP by forming a complex with BRCA2, RAD51, RPA and PALB2.
    1. Neuroscience

    Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area

    Elina Nagaeva et al.
    The midbrain area for salience, reward and aversion in mouse brain harbours among the dopamine cells three subtypes somatostatin-expressing neurons that show combinatorial neurotransmitter phenotypes and interneuron properties.
    1. Chromosomes and Gene Expression

    YTH-RNA-binding protein prevents deleterious expression of meiotic proteins by tethering their mRNAs to nuclear foci

    Yuichi Shichino et al.
    A YTH-domain protein Mmi1 prevents deleterious expression of meiotic proteins by tethering their mRNAs to nuclear foci.
    1. Neuroscience

    Hipposeq: a comprehensive RNA-seq database of gene expression in hippocampal principal neurons

    Mark S Cembrowski et al.
    Gene expression was analyzed in hippocampal principal cells, enabling cellular phenotyping and revealing novel organizational principles; complementing this, a publicly available website is released to provide outside analysis and visualization of hippocampal RNA-seq data in an accessible fashion.
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    Adult axolotls can regenerate original neuronal diversity in response to brain injury

    Ryoji Amamoto et al.
    Upon injury, the regeneration of the adult axolotl brain rebuilds neuronal diversity, but alters the original long-distance circuitry and tissue architecture.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    An advanced cell cycle tag toolbox reveals principles underlying temporal control of structure-selective nucleases

    Julia Bittmann et al.
    The development of an advanced cell cycle tag toolbox will enable a wide variety of cell cycle studies and shows post-replicative function of nucleases resolving replication/recombination structures.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Genetic interactions of G-quadruplexes in humans

    Katherine G Zyner et al.
    For the first time, the spectrum of genes and pathways interacting with alternative DNA structures called G-quadruplexes in humans is revealed highlighting new possibilities for the pursuit of cancer therapies.
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