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    1. Developmental Biology
    2. Genetics and Genomics

    ARID1A governs the silencing of sex-linked transcription during male meiosis in the mouse

    Debashish U Menon, Prabuddha Chakraborty ... Terry Magnuson
    ARID1A is implicated in BAF-A-governed meiotic sex chromosome gene regulation and sex-linked chromatin dynamics in DNA repair.
    1. Neuroscience

    Integration of overlapping sequences emerges with consolidation through medial prefrontal cortex neural ensembles and hippocampal–cortical connectivity

    Alexa Tompary, Lila Davachi
    Changes in cortical neural ensembles and heightened coupling between the hippocampus and cortex enable the eventual behavioral integration of memories with overlapping sequential information.
    1. Neuroscience

    Direct observation of the neural computations underlying a single decision

    Natalie Steinemann, Gabriel M Stine ... Michael N Shadlen
    Simultaneous recording from many neurons in macaque lateral intraparietal area reveals the elusive drift-diffusion signal, long suspected to underlie individual perceptual decisions and response times.
    1. Computational and Systems Biology
    2. Neuroscience

    White matter structural bases for phase accuracy during tapping synchronization

    Pamela Garcia-Saldivar, Cynthia de León ... Hugo Merchant
    Comparison between tapping performance of humans during a synchronization task and new metrics that characterize the U-fiber system of white matter revealed large intersubject correlations between phase accuracy at specific tempos and the strength of connectivity in their audiomotor system.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

    Jiale Zhou, Ding Zhao ... Zhanjun Li
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Immunology and Inflammation

    Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice

    Alessandra Machado Araujo, Joseph D Dekker ... Haley O Tucker
    Single-cell RNA-seq data and transgenic models revealed B-plasmacytoid dendritic cells (B-pDCs) represent a phenotypically and functionally distinct common lymphoid progenitor-derived pDC lineage specialized in T cell activation and previously not described in mice.
    1. Cell Biology
    2. Developmental Biology

    H2A.Z deposition at meiotic prophase I underlies homologous recombination and pachytene genome activation during male meiosis

    Shenfei Sun, Yamei Jiang ... Xinhua Lin
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    The components of an electrical synapse as revealed by expansion microscopy of a single synaptic contact

    Sandra P Cárdenas-García, Sundas Ijaz, Alberto E Pereda
    Anatomical study reveals a new perspective on the definition of an electrical synapse where, in addition to the communicating role of gap junctions, additional cellular structures might be involved in the support and regulation of these intercellular channels.
    1. Neuroscience

    Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation

    Elizabeth C Marin, Billy J Morris ... Gregory SXE Jefferis
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Cell Biology

    Vacuolar H+-ATPase determines daughter cell fates through asymmetric segregation of the nucleosome remodeling and deacetylase complex

    Zhongyun Xie, Yongping Chai ... Wei Li
    Asymmetric segregation of V-ATPase may cause distinct acidification levels in the two daughter cells, enabling asymmetric epigenetic inheritance that specifies their respective life-versus-death fates.