4,869 results found
    1. Cell Biology

    The GARP complex is required for cellular sphingolipid homeostasis

    Florian Fröhlich et al.
    The retrograde vesicular trafficking GARP complex, which is mutated in a neurodegenerative disease, is important for sphingolipid homeostasis in yeast and mammalian cells.
    1. Ecology
    2. Neuroscience

    Olfactory channels associated with the Drosophila maxillary palp mediate short- and long-range attraction

    Hany KM Dweck et al.
    Drosophila's second nose, the maxillary palp, is involved in short- and long-range attraction.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genome mining unearths a hybrid nonribosomal peptide synthetase-like-pteridine synthase biosynthetic gene cluster

    Hyun Bong Park et al.
    A new type of hybrid nonribosomal peptide synthetase (NRPS)-like-pteridine synthase biosynthetic pathway has been illuminated via genome mining.
    1. Neuroscience

    Risk of punishment influences discrete and coordinated encoding of reward-guided actions by prefrontal cortex and VTA neurons

    Junchol Park, Bita Moghaddam
    Risk of punishment during reward seeking behavior is associated with a functional "disconnection" of the PFC-VTA circuit due to a transient loss of VTA-driven theta oscillation.
  1. Scientist and Parent: Part of the research family

    Emma Pewsey
    eLife is publishing a collection of articles and interviews with scientists who are parents to explore how to get the best of both worlds.
    1. Cell Biology
    2. Neuroscience

    The p38 MAP kinase pathway modulates the hypoxia response and glutamate receptor trafficking in aging neurons

    Eun Chan Park, Christopher Rongo
    The subcellular localization of the prolyl hydroxylase oxygen sensor in C. elegans neurons is regulated by p38 MAP kinase signaling.
    1. Immunology and Inflammation

    The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1+ lymph node macrophages

    Chung Park et al.
    Lymph node gp120 specific B cells extract locally injected HIV-1 gp120 from SIGN-R1 positive macrophages that line the subcapsular sinus overlying the lymph node interfollicular channels.
  2. Scientific Publishing: Launching eLife, Part 1

    Randy Schekman et al.
    The new open-access journal eLife has launched, making its first content available in PubMed Central. In addition to publishing science of the highest quality, the journal aims to improve both the peer-review process and the presentation of new research results.
    Editorial
    Available as:
    • HTML
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    1. Neuroscience

    Learning induces the translin/trax RNase complex to express activin receptors for persistent memory

    Alan Jung Park et al.
    Combination of in vitro and in vivo approaches reveal how learning suppresses the microRNA system to trigger de novo synthesis of plasticity proteins, a missing link in the current model of microRNA-mediated translation in persistent synaptic plasticity and memory.

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