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    1. Cancer Biology

    Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies

    Sander Frank, Thomas Persse ... Peter S Nelson
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Cancer Biology

    STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer

    Huan Fang, Huichun Liang ... Ceshi Chen
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    HIF1A contributes to the survival of aneuploid and mosaic pre-implantation embryos

    Estefania Sanchez-Vasquez, Marianne E Bronner, Magdalena Zernicka-Goetz
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Convincing
    1. Immunology and Inflammation

    Functional identification of soluble uric acid as an endogenous inhibitor of CD38

    Shijie Wen, Hiroshi Arakawa ... Ikumi Tamai
    Soluble uric acid at physiological levels limits NAD+ degradation and excessive inflammation by directly inhibiting CD38.
    1. Biochemistry and Chemical Biology

    Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays

    Jonathan G Van Vranken, Jiaming Li ... Devin K Schweppe
    An approachable framework for the scalable implementation of proteome-wide thermal shift assays to assess drug mechanisms of action.
    1. Cell Biology

    Image Correlation Spectroscopy is a Robust Tool to Quantify Cellular DNA Damage Response

    Angelica A Gopal, Bianca Fernandez ... J Matthew Dubach
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology
    2. Cancer Biology

    Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

    Chong Zhang, Zuoyan Zhang ... Yangling Li
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Stem Cells and Regenerative Medicine

    Regeneration following tissue necrosis is mediated by non-apoptotic caspase activity

    Jacob W Klemm, Chloe Van Hazel, Robin E Harris
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Solid
    1. Neuroscience

    DBT is a metabolic switch for maintenance of proteostasis under proteasomal impairment

    Ran-Der Hwang, YuNing Lu ... Jiou Wang
    A genome-wide screen identifies the BCAA catabolizing enzyme DBT as a master metabolic switch in the regulation of protein quality control when proteasomal activity is impaired.
    1. Immunology and Inflammation

    Apoptotic caspases cleave DRP1 to promote mitochondrial fusion and anti-viral immune responses

    Yujie Fang, Zihan Guan ... Ke Peng
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
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