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    1. Neuroscience

    Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls

    Swagata Ghatak et al.
    Increased excitation and decreased inhibition associated with abnormal neuronal morphology, aberrant ion channel properties, and synaptic dysfunction contribute to hyperexcitability in Alzheimer’s disease hiPSC-derived neuronal cultures and cerebral organoids.
    1. Neuroscience

    Inhibiting poly(ADP-ribosylation) improves axon regeneration

    Alexandra B Byrne et al.
    In C. elegans and mouse neurons, the balance between poly(ADP-ribose) glycohydrolases and poly(ADP-ribose) polymerases regulates axon regeneration downstream of DLK-1/MAPKKK signaling.
    1. Neuroscience

    Functional effects of distinct innervation styles of pyramidal cells by fast spiking cortical interneurons

    Yoshiyuki Kubota et al.
    Cortical interneurons inhibit pyramidal cells to a greater degree when they form synapses with the pyramidal cell body than when they form synapses with dendrites.
    1. Cell Biology

    A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction

    Mira I Pronobis et al.
    A new dynamic mechanistic model explains how the destruction complex negatively regulates Wnt signaling in development and oncogenesis.
    1. Cell Biology

    Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

    Scott J Dixon et al.
    Erastin and sorafenib inhibit system xc- and induce ER stress, suggesting these may be useful tools for probing the functions of system xc- and its role in inducing ER stress and ferroptosis.
    1. Cancer Biology

    A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

    Joanna L Gillis et al.
    A positive feedback loop between the androgen receptor and a key pentose phosphate pathway enzyme, 6PGD, in prostate cancer promotes tumour cell proliferation, survival and intracellular redox control.
    1. Cell Biology

    Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5

    Illyce Nuñez et al.
    NDR kinase Orb6 prevents RNP granule assembly and translational repression by promoting Sts5 association with 14-3-3 protein Rad24 to spatially control polarized cell growth.
    1. Plant Biology

    Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors

    Alexey Shapiguzov et al.
    Signalling and metabolic interactions of the plant energy organelles, chloroplasts and mitochondria, depend on the nuclear regulatory protein RCD1.
    1. Cancer Biology
    2. Cell Biology

    p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway

    Pauline Jeannot et al.
    p27Kip1 directly controls invadopodia turnover by promoting the interaction of PAK1 with Cortactin, which induces Cortactin phosphorylation, invadopodia disassembly and facilitates invasion through extracellular matrix.